H4C14: A Potential Drug Target for Cancer (G8370)

Target Name: H4C14

NCBI ID: G8370

H4C14

Other Name(s): H4F2 | Histone H4 | H4FN | HIST2H4 | translation initiation factor IF-2-like | histone cluster 2 H4 family member a | H4 histone, family 2 | histone IV, family 2 | H4 histone family, member N | H4C8 | FO108 | H4_HUMAN | H4C12 | H4 | H4C11 | H4C9 | histone cluster 2, H4a | histone 2, H4a | H4C5 | H4 clustered histone 14 | HIST2H4A | H4/n | H4C6 | H4C16 | H4C15 | H4C3 | H4C1 | H4C4 | H4C13 | H4C2 | H4-16

H4C14: A Potential Drug Target for Cancer

H4C14, also known as H4F2, is a protein that is expressed in various tissues throughout the body. It is a key regulator of the cell cycle, which is the process by which cells grow, divide, and replicate their genetic material. H4C14 plays a crucial role in controlling the length of the cell cycle, and is therefore considered a potential drug target (or biomarker).

H4C14 is a protein composed of a single polypeptide chain, which is 41 amino acids in length. It consists of two domains: N-terminal domain and C-terminal domain. The N-terminal domain includes an 伪-helix, a 尾-sheet, and two hydrophobic helices. The C-terminal domain includes an 伪-helix, a 尾-sheet, and a short amino acid sequence.

H4C14 regulates cyclin activity during the cell cycle. It interacts with CDK2 (cyclin D1), which is a key protein in the cell cycle. H4C14 modulates the activity of CDK2 by interacting with its 伪-helix. This interaction leads to changes in the 伪-helix of H4C14, thereby affecting the activity of CDK2.

H4C14 also plays an important role in tumorigenesis. Studies have shown that H4C14 expression levels are positively correlated with various types of cancer, including breast, lung and prostate cancer. In addition, the expression level of H4C14 is also related to tumor invasion and metastasis. Therefore, H4C14 is considered an important drug target (or biomarker) for the treatment of various cancers.

H4C14's drug target (or biomarker) potential mainly stems from its mechanism of action. Since H4C14 regulates the activity of CDK2 during the cell cycle, the activity of H4C14 can be inhibited by interfering with the CDK2 signaling pathway. In addition, the C-terminal domain of H4C14 contains a short amino acid sequence, which makes it easy to modify. By adding specific drugs to the C-terminal domain of H4C14, the activity of CDK2 can be modulated and the growth and spread of tumor cells can be inhibited.

H4C14 has been widely used in drug screening and tumor treatment. For example, studies have shown that H4C14 can inhibit the growth of cancer cells such as breast, lung and prostate cancer. In addition, the detection of H4C14 is also used to evaluate the invasiveness and metastasis of tumors, as well as to evaluate the efficacy of drugs on tumors.

However, H4C14 also has some challenges as a drug target (or biomarker). Research on H4C14 mainly focuses on the cellular level and biochemical level. For clinical applications in drug screening and tumor treatment, the activity of H4C14 requires further study. In addition, the expression level of H4C14 is also affected by various factors, including age, gender, lifestyle and tumor type. Therefore, these factors need to be fully considered in drug screening and tumor treatment of H4C14.

H4C14 is a protein that regulates cyclin activity during the cell cycle. It also plays an important role in tumorigenesis. The drug target (or biomarker) potential of H4C14 mainly stems from its mechanism of action. By interfering with the CDK2 signaling pathway and regulating CDK2 activity, H4C14 can inhibit the growth and spread of tumor cells. H4C14 has been widely used in drug screening and tumor treatment, but further research is needed.

Protein Name: H4 Clustered Histone 14

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

The "H4C14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H4C14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets