WDR83: A Potential Drug Target and Biomarker for Neurodegenerative Disorders, Cancer and Cardiovascular Disease

Target Name: WDR83

NCBI ID: G84292

WDR83

WDR83: A Potential Drug Target and Biomarker for Neurodegenerative Disorders, Cancer and Cardiovascular Disease

WDR83, also known as WDR83 protein, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the WD repeat domain family, which is a conserved group of proteins that are Characterized by the presence of a specific repeat sequence in their amino acid sequence. The WD repeat domain is known for its ability to form a disulfide bond, which is thought to play a role in the protein's stability and function.

Recent studies have identified WDR83 as a potential drug target and biomarker for various diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. In this article, we will explore the biology and potential clinical applications of WDR83.

Biochemistry and localization

WDR83 is a 21-kDa protein that consists of 115 amino acids. It is expressed in various tissues of the body, including the brain, heart, and kidneys. The protein is predominantly localized to the cytoplasm of the cells in which it is expressed, and is not detected in the cell nucleus.

Structure and mechanism

The WD repeat domain is a conserved group of proteins that is characterized by the presence of a specific repeat sequence in their amino acid sequence. The WD repeat domain is composed of a series of amino acids that are similar in sequence to the protein alpha-helices , which are regions of the protein that are involved in the formation of helices. These amino acids form a disulfide bond, which is thought to play a role in the protein's stability and function.

WDR83 is a member of the WD repeat domain family and has a similar structure to other members of this family, such as WDR81 and WDR82. It consists of a single exon that is located between the amino acids Asp2 and Asn3. The protein has a calculated pI of 4.8 and a predicted localization in the cytoplasm of the cells in which it is expressed.

Function and regulation

WDR83 is involved in various cellular processes that are important for the survival and function of cells. It is a component of the endoplasmic reticulum, which is the system for transporting proteins from the cytoplasm to the endoplasmic reticulum. It is also involved in the regulation of cellular processes that are important for cell survival, such as cell growth, apoptosis, and inflammation.

In addition to its role in cellular processes, WDR83 is also a potential drug target and biomarker for various diseases. Its ability to form a disulfide bond and its conservation in various species make it an attractive target for drug development.

Potential clinical applications

WDR83 has the potential to be a drug target for various diseases, including neurodegenerative disorders, cancer, and cardiovascular disease.

In neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, the loss of WDR83 has been observed in the brain and is thought to contribute to the progression of the disease. Therefore, targeting WDR83 with drugs that can promote its expression or protect it from degradation may be a promising strategy for the treatment of these disorders.

In cancer, WDR83 has been identified as a potential biomarker for various types of cancer, including lung, breast, and ovarian cancer. Its expression has been observed in various types of cancer, and its levels have been correlated with the severity of the disease. Therefore, targeting WDR83 with drugs that can inhibit its expression or activity may be a promising strategy for the treatment of cancer.

In cardiovascular disease, WDR83 has been identified as a potential

Protein Name: WD Repeat Domain 83

Functions: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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