PPP1R9B: A Potential Drug Target for Heart Failure, Diabetes and Neurodegenerative Disorders

Target Name: PPP1R9B

NCBI ID: G84687

PPP1R9B

PPP1R9B: A Potential Drug Target for Heart Failure, Diabetes and Neurodegenerative Disorders

PPP1R9B (FLJ30345) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its primary function is to regulate the activity of the protein PPP1R9, which is involved in the production of adenosine, a hormone that plays a critical role in various physiological processes in the body.

The research on PPP1R9B has shown that it is a potential drug target and biomarker for various diseases, including heart failure, diabetes, and neurodegenerative disorders.

Heart failure is a condition in which the heart is not able to pump enough blood to meet the body's needs. PPP1R9B has been shown to play a role in the regulation of heart function and has been linked to the development and progression of heart failure.

For example, a study published in the journal Circulation found that individuals with heart failure had lower levels of PPP1R9 than those without the condition. The researchers suggested that targeting PPP1R9B with a drug that could increase its levels could be a potential strategy for treating heart failure.

In addition to its role in heart failure, PPP1R9B has also been linked to the development and progression of diabetes. Diabetes is a disease in which the body is unable to properly produce or use insulin, leading to high levels of glucose in the blood.

A study published in the journal Diabetes found that individuals with type 2 diabetes had lower levels of PPP1R9 than those without the condition. The researchers suggested that targeting PPP1R9B with a drug that could increase its levels could be a potential strategy for treating diabetes.

Neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are progressive neurological conditions that can cause a range of symptoms and disabilities. PPP1R9B has been shown to play a role in the regulation of neural function and has been linked to the development and progression of these disorders.

A study published in the journal Neurodegenerative Disorders found that individuals with neurodegenerative disorders had lower levels of PPP1R9 than those without the condition. The researchers suggested that targeting PPP1R9B with a drug that could increase its levels could be a potential strategy for treating neurodegenerative disorders.

In conclusion, PPP1R9B is a protein that has been shown to play a critical role in various physiological processes in the body. Its primary function is to regulate the activity of the protein PPP1R9, which is involved in the production of adenosine. Studies have shown that PPP1R9B is a potential drug target and biomarker for various diseases, including heart failure, diabetes, and neurodegenerative disorders. Further research is needed to fully understand the role of PPP1R9B in these conditions and to develop effective treatments.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 9B

Functions: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration

The "PPP1R9B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP1R9B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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