PLPP3: Key Enzyme in PI Signaling Pathway and Potential Drug Target

Target Name: PLPP3

NCBI ID: G8613

PLPP3

PLPP3: Key Enzyme in PI Signaling Pathway and Potential Drug Target

Phosphatidate phosphohydrolase type 2b (PLPP3) is a protein that is expressed in various tissues and cells throughout the body. It is a key enzyme in the phosphatidylinositol (PI) signaling pathway, which is involved in a wide range of cellular processes, including cell signaling , protein synthesis, and inflammation. PLPP3 is also a potential drug target and biomarker for various diseases.

The PI signaling pathway is a complex system that involves the recruitment of various enzymes and substrates to the protein known as PIP2, which is a key regulator of the pathway. The pathway is involved in the regulation of many cellular processes, including cell growth, differentiation, and survival. PLPP3 is one of the enzymes that is involved in the breakdown of PIP2 to generate PIP3, which is a key signaling molecule.

PLPP3 is a member of the PLC/A subfamily of the phospholipase C (PLC) family. PLC is a family of enzymes that are involved in the breakdown of phospholipids, which are the major components of cell membranes. The PLC/A subfamily includes several different enzymes, including PLA2, PLB, PLPP3, and PLC纬. These enzymes are involved in the production of various phospholipids, including PIP2 and PIP3.

PLPP3 is involved in the regulation of cellular signaling pathways that are involved in many different cellular processes, including cell growth, differentiation, and survival. For example, PLPP3 is involved in the regulation of cell survival and has been shown to play a role in the development of cancer. PLPP3 has also been shown to be involved in the regulation of cell proliferation and has been linked to the development of various types of cancer.

PLPP3 is also involved in the regulation of protein synthesis and has been shown to play a role in the regulation of protein synthesis. PLPP3 is known to interact with several different protein partners, including several transcription factors. These protein partners are involved in the regulation of cellular processes, including gene expression, DNA replication, and protein synthesis.

PLPP3 is also involved in the regulation of inflammation and has been shown to play a role in the development of various types of inflammation. PLPP3 has been shown to be involved in the production of pro-inflammatory cytokines, such as TNF-伪 and IL- 1尾. These cytokines are involved in the regulation of immune responses and have been linked to the development of various types of inflammation.

PLPP3 is a potential drug target and biomarker for various diseases. For example, PLPP3 has been shown to be involved in the regulation of cancer cell survival and has been linked to the development of cancer. PLPP3 has also been shown to be involved in the regulation of inflammation and has been linked to the development of various types of inflammation.

In conclusion, PLPP3 is a protein that is involved in the regulation of various cellular processes that are important for cellular survival and function. PLPP3 is a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of PLPP3 in cellular processes and to develop effective treatments for PLPP3-related diseases.

Protein Name: Phospholipid Phosphatase 3

Functions: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9705349, PubMed:9607309, PubMed:27694435). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:9607309, PubMed:23591818, PubMed:27694435). Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (PubMed:27694435). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (PubMed:23591818)

The "PLPP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLPP3 comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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