ND1 Plays A Crucial Role in NADH Biosynthesis and Electron Transport Chain of Mitochondria

Target Name: ND1

NCBI ID: G4535

Content of Review Report on ND1 Target / Biomarker

ND1

ND1 Plays A Crucial Role in NADH Biosynthesis and Electron Transport Chain of Mitochondria

NADH-ubiquinone oxidoreductase chain 1 (ND1) is a enzyme that plays a critical role in the electron transport chain of the mitochondria. It is a key component of the NADH biosynthesis pathway, which is central to the production of energy by the cell through the process of cellular respiration. ND1 is a protein that consists of four subunits, which are encoded by the genomic sequence GAAATGACGAA (C. subtilis) and GAAATGAAAT (E. coli).

The NADH biosynthesis pathway is a complex series of chemical reactions that involve the transfer of electrons from the cytoplasm to the mitochondrial matrix. ND1 is involved in the transfer of electrons from the cytoplasm to the mitochondrial matrix. In this process, ND1 acts as a electron carrier, transferring electrons from the cytoplasm to the mitochondrial matrix. ND1 is also involved in the production of NAD+, which is a critical co-factor for many cellular processes, including the production of ATP, the synthesis of nucleotides, and the detoxification of harmful substances.

ND1 is a protein that is expressed in most cell types of higher eukaryotes. It is a cytoplasmic protein and is primarily located in the mitochondria. ND1 is a monomeric protein, which means that it is composed of a single polypeptide chain. The four subunits of ND1 are located at different positions on the protein sequence. The first subunit is located at the N-terminus of the protein, the second subunit is located at the C-terminus, the third subunit is located in the middle of the protein, and the fourth subunit is located at the C-terminus.

The ND1 enzyme has a critical role in the electron transport chain of the mitochondria. It is involved in the transfer of electrons from the cytoplasm to the mitochondrial matrix. In this process, ND1 acts as an electron carrier, transferring electrons from the cytoplasm to the mitochondrial matrix. ND1 is also involved in the production of NAD+, which is a critical co-factor for many cellular processes, including the production of ATP, the synthesis of nucleotides, and the detoxification of harmful substances.

ND1 is a protein that is expressed in most cell types of higher eukaryotes. It is a cytoplasmic protein and is primarily located in the mitochondria. The function of ND1 is to participate in the electron transport chain of the mitochondria. It is a key component of the NADH biosynthesis pathway, which is central to the production of energy by the cell through the process of cellular respiration.

In conclusion, ND1 (NADH-ubiquinone oxidoreductase chain 1) is a protein that plays a critical role in the electron transport chain of the mitochondria. It is a key component of the NADH biosynthesis pathway, which is central to the production of energy by the cell through the process of cellular respiration. ND1 is a protein that is expressed in most cell types of higher eukaryotes and is primarily located in the mitochondria. Its function is to participate in the electron transport chain of the mitochondria and is a potential drug target or biomarker.

Protein Name: Mitochondrially Encoded NADH Dehydrogenase 1

Functions: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:1959619). Essential for the catalytic activity and assembly of complex I (PubMed:26929434, PubMed:1959619)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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