NCS1: A Protein Focus of Interest for Drug Targets and Biomarkers

Target Name: NCS1

NCBI ID: G23413

NCS1

NCS1: A Protein Focus of Interest for Drug Targets and Biomarkers

NCS1, or Neuronal Calcium Sensor 1, is a protein that is expressed in high levels in the brain and is involved in the regulation of neuronal activity. It is a type of calcium sensor that can detect changes in calcium levels in the brain, which is important for the function of neurons. Mutations in the NCS1 gene have been linked to a number of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. As a result, NCS1 has become a focus of interest for researchers as a potential drug target or biomarker.

The NCS1 protein is composed of 192 amino acids and has a calculated molecular mass of 21.9 kDa. It is expressed in the brain and is involved in the regulation of neuronal activity. NCS1 is a type of calcium sensor that can detect changes in calcium levels in the brain, which is important for the function of neurons. It is a protein that is expressed in the brain and is involved in the regulation of neuronal activity.

Studies have shown that NCS1 is involved in a number of important cellular processes in the brain, including cell signaling, neurotransmitter release, and synaptic plasticity. NCS1 has been shown to play a role in the regulation of neuronal activity, and is involved in the transmission of signals between neurons.

Mutations in the NCS1 gene have been linked to a number of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Researchers are interested in using NCS1 as a potential drug target or biomarker because of its involvement in these disorders.

One way that researchers are using NCS1 as a drug target is by targeting the protein using small molecules. This is done by using a technique called protein-based drug discovery, which involves using small molecules to identify potential drugs that can interact with specific proteins. Researchers have identified a number of small molecules that have been shown to interact with NCS1 and have the potential to be used as drugs.

Another way that researchers are using NCS1 as a biomarker is by using it to track the progression of disease. This is done by using NCS1 to track the levels of the protein in the brain over time, which can provide information about the effectiveness of a drug or the progression of a disease. This has been done using a technique called neuroimaging, which involves using NCS1 to track the levels of the protein in the brain over time using techniques such as positron emission tomography (PET) or functional magnetic resonance imaging (fMRI).

Research has also shown that NCS1 levels can be used as a biomarker for certain psychiatric disorders, such as depression and anxiety. This is done by using NCS1 levels to track changes in the brain over time, which can provide information about the effectiveness of a drug or the progression of a disease.

In conclusion, NCS1 is a protein that is expressed in the brain and is involved in the regulation of neuronal activity. Mutations in the NCS1 gene have been linked to a number of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. As a result, NCS1 has become a focus of interest for researchers as a potential drug target or biomarker. The use of small molecules and neuroimaging techniques is being explored as ways to study the effects of drugs on NCS1 levels in the brain.

Protein Name: Neuronal Calcium Sensor 1

Functions: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity)

The "NCS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NCS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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