Understanding NCR3: The Protein That May Hold The Key To Cancer Treatment

Target Name: NCR3

NCBI ID: G259197

NCR3

Understanding NCR3: The Protein That May Hold The Key To Cancer Treatment

Natural cytotoxicity triggering receptor 3 (NCR3), also known as ISOform B, is a protein that is expressed in various tissues throughout the body. It plays a crucial role in the immune response and has been implicated in the development and progression of various diseases, including cancer.

One of the key functions of NCR3 is its ability to recognize and respond to damage caused to cells by stressors, such as UV radiation, chemical agents, and radiation. This recognition is important for triggering an immune response, which is critical for maintaining tissue health and preventing the development of diseases.

NCR3 is also involved in the regulation of cell death, which is an important part of the immune response. When cells are damaged or have been exposed to stressors, NCR3 helps to induce programmed cell death, also known as apoptosis, which allows the body to remove damaged cells and prevent the spread of disease.

NCR3 has also been shown to play a role in the development of certain types of cancer. For example, studies have shown that high levels of NCR3 are associated with an increased risk of pancreatic cancer. Additionally, NCR3 has also been shown to be involved in the development of breast cancer.

Due to its involvement in the immune response and its potential role in the development of certain types of cancer, NCR3 has become a focus of interest for researchers. One of the ways that researchers are trying to understand NCR3 is by studying its role in cancer progression.

One potential approach to studying NCR3 is through the use of drugs that can activate its activity. Researchers are interested in developing drugs that can specifically target NCR3 and trigger its response to stressors. This could be useful for the treatment of certain types of cancer, as well as for preventing the development of cancer in at-risk individuals.

Another approach to studying NCR3 is through the use of biomarkers. Researchers are interested in developing biomarkers that can be used to predict the risk of cancer or the progression of cancer. NCR3 has been shown to be a potential biomarker for cancer, and researchers are working to develop methods for its detection and quantification in biological tissues, body fluids and clinical samples.

NCR3 is also of interest to researchers because of its potential role in the development of autoimmune diseases. Autoimmune diseases occur when the immune system attacks the body's own tissues, and they are a leading cause of chronic diseases, including cancer. NCR3 has been shown to be involved in the development and progression of autoimmune diseases, and researchers are working to understand its role in this process.

In conclusion, NCR3 is a protein that is expressed in various tissues throughout the body that plays a crucial role in the immune response and has been implicated in the development and progression of various diseases, including cancer. The activation of NCR3 by drugs or biomarkers could be a promising approach to the treatment of certain types of cancer and the prevention of cancer in at-risk individuals. Further research is needed to fully understand the role of NCR3 in the immune response and its potential as a drug target or biomarker.

Protein Name: Natural Cytotoxicity Triggering Receptor 3

Functions: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation

The "NCR3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NCR3 comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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