Understanding The Role of ND4 in NADH and NAD+ Production (G4538)

Target Name: ND4

NCBI ID: G4538

Content of Review Report on ND4 Target / Biomarker

ND4

Understanding The Role of ND4 in NADH and NAD+ Production

NADH dehydrogenase subunit 4 (ND4) is a protein that is expressed in most tissues in the body. It is a key enzyme in the electron transport chain of the cell, which is responsible for producing the energy needed by the cell. ND4 is composed of two subunits, which are held together by a disulfide bond.

The function of ND4 is to convert NAD+, which is a crucial coenzyme found in all cells, into NADH. NADH is a key electron carrier that is involved in the production of ATP, the energy currency of the cell. When NAD+ is converted to NADH , a proton is released from the electron carrier and is added to the electron chain. This process is reversible, and when NADH is converted back to NAD+, the proton is added back to the electron chain.

ND4 is a critical enzyme for the production of NADH, which is essential for the function of many cellular processes. NADH is involved in the production of ATP, as well as the metabolism of fats and carbohydrates. It is also involved in the production of cereals Thione, a protein that protects cells from oxidative stress.

ND4 is also involved in the regulation of cellular processes. For example, it is involved in the production of superoxide, which is a reactive oxygen species that can cause damage to cells. Superoxide can be produced by processes such as cellular respiration, but it can also be produced by other processes that involve the oxidation of nutrients. ND4 helps to regulate the production of superoxide, which is important for the survival of cells that are exposed to oxidative stress.

ND4 is also involved in the regulation of cell growth. It is has been shown to play a role in the regulation of cell proliferation, and it is thought to be involved in the G1/S transition, which is the process by which cells prepare for cell division.

ND4 is also a potential drug target. The ability of ND4 to produce NADH and NAD+ makes it an attractive target for pharmacologists because it is involved in the production of the energy and antioxidant NAD+. NAD+ has been shown to have a number of potential health benefits , including its ability to reduce inflammation, improve athletic performance, and promote brain health.

In addition, ND4 is also a potential biomarker for a number of diseases. For example, people with certain genetic disorders, such as those with a condition called Wilson's disease, have defective ND4 and are unable to produce enough NADH. This can lead to the accumulation of toxic levels of NAD+, which can cause a number of symptoms, including liver damage, nerve damage, and cognitive impairment.

The study of ND4 and its role in the production of NADH and NAD+ is an active area of 鈥嬧?媟esearch, with a number of studies investigating its function and potential as a drug target. For example, researchers have shown that inhibiting the activity of ND4 can be an effective way to treat a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular disease.

In addition, there are also efforts to develop ND4 as a diagnostic biomarker. Researchers have shown that ND4 is expressed in a variety of tissues and that it is involved in the production of NADH and NAD+. This makes it an attractive target for diagnostic studies, and there is ongoing research to develop ND4 as a diagnostic biomarker for a variety of diseases.

In conclusion, ND4 is a protein that is involved in the production of NADH and NAD+, which are essential for the function of many cellular processes. It is also involved in the regulation of cellular processes and cell growth, and is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of ND4 in the production of NADH and NAD+ and its potential as a diagnostic biomarker.

Protein Name: Mitochondrially Encoded NADH Dehydrogenase 4

Functions: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:8644732, PubMed:8344246, PubMed:15250827). Essential for the catalytic activity and assembly of complex I (PubMed:8644732, PubMed:8344246, PubMed:15250827)

The "ND4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ND4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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