CFAP91: A Versatile Protein with Therapeutic Potential in Diseases

Target Name: CFAP91

NCBI ID: G89876

CFAP91

CFAP91: A Versatile Protein with Therapeutic Potential in Diseases

CFAP91 (AAT1alpha), a protein that belongs to the family of cysteinyl-proteinase (CPP) 91 (CPP91) family, plays a critical role in cell signaling pathways, specifically in the regulation of cell adhesion, angiogenesis, and tissue repair. Its function is highly conserved across various species, and its role in human health and disease has been extensively studied.

CFAP91 is a transmembrane protein that is expressed in various tissues and organs, including the brain, heart, kidneys, and intestine. It is involved in several cellular processes, including cell adhesion, migration, and the regulation of ion channels. CFAP91 functions as a negative regulator of the cadherin protein, which is a major regulator of cell-cell adhesion.

The AAT1alpha gene, located on chromosome 16, encodes a protein that contains a unique N-terminus that is rich in cysteine residues. Cysteine residues are known for their ability to form hydrogen bonds, which can modulate protein stability and function. The N-terminus of CFAP91 is rich in cysteine residues, which are involved in the formation of a disulfide bond. This disulfide bond is critical for protein stability and function, and its formation is regulated by various factors, including tyrosination and debugging.

CFAP91 is a versatile protein that can be targeted by small molecules for the development of new pharmaceuticals or diagnostic tools. One potential drug target for CFAP91 is the inhibition of its N-terminus cysteine residues, which can lead to the disruption of its protein structure and function. This can result in the inhibition of cell adhesion and migration, which can have therapeutic applications in various diseases, including cancer, neurodegenerative diseases, and immune disorders.

Another potential drug target for CFAP91 is its role in the regulation of cell apoptosis. CFAP91 has been shown to play a role in the regulation of cell apoptosis in various tissues and organs, including the brain. Its N-terminus cysteine residues have been shown to be involved in the formation of a disulfide bond, which is critical for the regulation of cell apoptosis. This suggests that the inhibition of CFAP91 N-terminus cysteine residues may have therapeutic applications in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

CFAP91 is also a potential biomarker for various diseases, including cancer. Its function in cell signaling pathways makes it an attractive target for the development of new diagnostic tools for cancer. The inhibition of CFAP91 N-terminus cysteine residues has been shown to have therapeutic effects in various types of cancer, including breast, ovarian, and colorectal cancers. This suggests that the targeting of CFAP91 N-terminus cysteine residues may be a promising approach for the development of new cancer diagnostics and therapies.

In conclusion, CFAP91 (AAT1alpha) is a versatile protein that plays a critical role in cell signaling pathways and has been extensively studied in various tissues and organs. Its function as a negative regulator of the cadherin protein and its role in the regulation of cell adhesion, migration, and apoptosis make it an attractive target for the development of new pharmaceuticals, diagnostic tools, and biomarkers for various diseases, including cancer. The inhibition of its N-terminus cysteine residues may have therapeutic applications in the treatment of neurodegenerative diseases and immune disorders.

Protein Name: Cilia And Flagella Associated Protein 91

Functions: Involved in sperm flagellum axonemal organization and function (PubMed:12223483, PubMed:32161152). May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity)

The "CFAP91 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CFAP91 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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