CFTR: Understanding An Important Cellular Protein (G1080)

Target Name: CFTR

NCBI ID: G1080

CFTR

CFTR: Understanding An Important Cellular Protein

CFTR (CFTR), also known as vesicle transport-mediated transport protein, is a molecule that plays an important role in organisms. It is involved in many cellular processes, including cell signaling, intracellular transport, and many processes in cell biology. In some genetic diseases, CFTR has also been found to be an abnormal gene, so the study of these diseases is also very meaningful.

CFTR is a membrane protein on the inner surface of the cell membrane. Its main function is to transport vesicles, which are intracellular transport structures. CFTR promotes vesicle trafficking by binding to receptors on the vesicle surface. In addition, CFTR can also bind some intracellular molecules, such as ATP and Na+, to provide energy and charge during vesicle transport.

CFTR plays an important role in many biological processes. For example, in the process of cell signaling, CFTR is a key molecule in the signal transduction pathway. When cells receive external signals, such as hormones or chemicals, CFTR binds to receptors on the cell membrane, triggering a series of signal transduction reactions. These signal transduction reactions can regulate many cellular processes, such as cell proliferation, apoptosis, and the open state of ion channels.

CFTR is also involved in many intracellular trafficking processes. For example, during the formation of synapses in neurons, CFTR can transport neurotransmitters, thereby enabling communication between neurons. During the process of erythropoiesis, CFTR can transport iron ions, thereby promoting the production of red blood cells. During liver metabolism, CFTR can transport molecules such as fat and protein, thereby participating in liver metabolism.

CFTR also plays an important role in some genetic diseases. For example, SCN (SCN) is a genetic disorder characterized by abnormally elevated levels of intracellular iron. Studies have found that CFTR plays an important role in SCN, because abnormal CFTR genes can lead to abnormal increases in intracellular iron content. In addition, variations in the CFTR gene are also associated with many genetic diseases, such as vesicular transport disease (POMC) and glutathione-binding oxidoreductase deficiency (GSRO).

CFTR is also of high value in drug research and development. Since CFTR plays an important role in many biological processes, studying CFTR as a drug target has high prospects. For example, some studies have proven that CFTR can be used as a drug target to treat certain genetic diseases, such as SCN and POMC. In addition, CFTR also interacts with many drugs, such as antidepressants and antihypertensive drugs.

CFTR plays an important role in organisms and is also of high value in drug research and development. Therefore, research on CFTR will continue to be in-depth to better understand its role in organisms and provide new treatment options for the treatment of many genetic diseases.

Protein Name: CF Transmembrane Conductance Regulator

Functions: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810)

The "CFTR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CFTR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets