Unveiling the Potential Drug Target and Biomarker CCDC120: A unique protein for the Treatment of Neurological Disorders

Target Name: CCDC120

NCBI ID: G90060

CCDC120

Unveiling the Potential Drug Target and Biomarker CCDC120: A unique protein for the Treatment of Neurological Disorders

Introduction

Neurological disorders have long been a source of suffering and loss of quality of life for millions of people worldwide. Some of the most debilitating and life-threatening conditions include Alzheimer's disease, Parkinson's disease, and multiple sclerosis. These disorders are characterized by the progressive loss of brain cells, leading to a range of symptoms such as memory loss, cognitive impairment, and motor weakness. There is currently no cure for these conditions, and existing treatments are often limited in their effectiveness and safety. Therefore, there is a need for new and innovative therapies that can provide effective relief from these debilitating conditions.

In this article, we focus on the CCDC120 protein, which is a unique protein that has the potential to be a drug target or biomarker for the treatment of neurological disorders. We will explore the structure and function of CCDC120, its potential as a drug target , and its potential as a biomarker for the diagnosis and monitoring of these disorders.

Structure and Function of CCDC120

CDC120 is a protein that is expressed in a wide range of tissues and cells in the body. It is characterized by a unique structure that consists of a long coiled-coil domain and several short cytoplasmic domains. The coiled-coil domain is the protein's most distinctive feature, and it is responsible for the protein's ability to self-assemble to form secondary structure.

The CCDC120 protein has a molecular weight of approximately 11 kDa and a pre-folds structure of approximately 120 amino acids. It has a unique feature of having a coiled-coil domain that is composed of 19 amino acids. The coiled-coil domain is responsible for the protein's ability to self-assemble into a stable and functional secondary structure. The coiled-coil domain is also involved in the regulation of the protein's activity and stability.

CDC120's cytoplasmic domains are responsible for the protein's ability to interact with other proteins and for its localization to various cellular compartments. These domains include a short N-terminal domain that is involved in protein-protein interactions and a short C-terminal domain that is involved in the interaction with the cytoskeleton.

Potential as a Drug Target

CDC120's unique structure and function make it an attractive target for drug development. The coiled-coil domain and its self-assembly properties give it the potential to form aggregates that could be targeted by small molecules. Additionally, the protein's cytoplasmic domains suggest that it may interact with various cellular components, making it a potential target for drugs that target different cellular processes.

Several studies have suggested that CCDC120 may be a potential drug target for neurological disorders. For example, some studies have shown that inhibiting the activity of CCDC120 using small molecules can reverse the neurotoxicity associated with certain drugs. Additionally, the structure and function of CCDC120 suggest that it may be a potential biomarker for the diagnosis and monitoring of neurological disorders.

Potential as a Biomarker

CDC120's unique structure and function also make it an attractive target for use as a biomarker for the diagnosis and monitoring of neurological disorders. The protein's ability to self-assemble into a stable and functional secondary structure and its unique cytoplasmic domains suggest that it may be able to interact

Protein Name: Coiled-coil Domain Containing 120

Functions: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth

The "CCDC120 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCDC120 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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