CCDC154: A Potential Drug Target and Biomarker (G645811)

Target Name: CCDC154

NCBI ID: G645811

CCDC154

Other Name(s): Coiled-coil domain-containing protein 154 | C16orf29 | coiled-coil domain containing 154 | CC154_HUMAN | Coiled-coil domain containing 154

CCDC154: A Potential Drug Target and Biomarker

CDC154 is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidneys. It is a member of the superfamily of cytoskeletal proteins, which are involved in the regulation of cell shape and movement. Specifically, CDC154 is a coiled-coil domain-containing protein that is characterized by the presence of a unique protein domain that is composed of multiple coiled regions.

The functions of CDC154 are not well understood, but it is thought to play a role in the regulation of cellular processes that are important for the development, maintenance, and function of tissues. This protein is also of interest as a potential drug target, as it is expected to have unique properties that could make it an attractive target for small molecule inhibitors.

CDC154 Structure and Expression

The structure of CDC154 is unique, as it is composed of multiple coiled regions that are held together by a series of disulfide bonds. The protein has a length of approximately 300 amino acids and a calculated molecular mass of 46 kDa. It consists of a distinct N-terminal region that contains a putative nucleotide-binding domain (NBD), a catalytic domain, and a C-terminal region that is involved in the formation of a disulfide bond.

The NBD is a short, N-terminal region that contains a conserved core sequence that is characteristic of nucleotide-binding proteins. It is likely that CDC154 uses this domain to interact with nucleotides in the cell. The catalytic domain is a separate region of the protein that is responsible for the catalytic activity of the enzyme. It is composed of a parallel beta-sheet structure that is characterized by the presence of a central lobe and two distinct side lobes. The catalytic domain is likely responsible for the formation of the disulfide bonds that hold the protein together.

The C-terminal region of CDC154 is involved in the formation of a disulfide bond and consists of a short, linear sequence that is unique to this protein. It is likely that this region plays a role in the regulation of the disulfide bond formation that is critical for the stability and function of the protein.

Expression of CDC154

CDC154 is expressed in various tissues of the body, including the brain, heart, liver, and kidney. It is found in the cytoplasm of cells and is associated with the endoplasmic reticulum (ER). The expression of CDC154 is regulated by a variety of factors, including its concentration in the cell, the presence of bound nucleotides, and the presence of other proteins that interact with it.

CDC154 has been shown to play a role in the regulation of cellular processes that are important for the development, maintenance, and function of tissues. For example, studies have shown that CDC154 is involved in the regulation of cell proliferation, differentiation, and survival. It is also thought to be involved in the regulation of cellular signaling pathways that are important for the development and maintenance of tissues.

CDC154 as a Potential Drug Target

CDC154 is a unique protein that is characterized by the presence of a unique protein domain that is composed of multiple coiled regions. This protein domain is likely responsible for the unique functions of CDC154, and it is expected to be an attractive target for small molecule inhibitors.

One way to inhibit the activity of CDC154 is to use small molecules that interact with the coiled regions of the protein. This approach is based on the idea that the unique

Protein Name: Coiled-coil Domain Containing 154

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