PDLIM1: A Potential Drug Target for Neurodegenerative Diseases

Target Name: PDLIM1

NCBI ID: G9124

PDLIM1

PDLIM1: A Potential Drug Target for Neurodegenerative Diseases

PDLIM1 (C-terminal LIM domain protein 1) is a protein that is expressed in a variety of tissues, including the brain, heart, and kidneys, and is involved in the regulation of cell signaling pathways. The PDLIM1 gene was identified as a potential drug target in the field of neurodegenerative diseases, due to its involvement in the development and progression of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

The PDLIM1 protein is composed of 156 amino acid residues and has a calculated molecular weight of 19.9 kDa. It is localized to the endoplasmic reticulum and is predominantly expressed in the brain, with lower levels of expression found in the heart and kidneys. The PDLIM1 protein is involved in the regulation of several cellular signaling pathways, including the TGF-β pathway, the Wnt pathway, and theNotch pathway.

The TGF-β pathway is a well-established mechanism of neurodegeneration that is involved in the development and progression of a variety of neurodegenerative diseases. The PDLIM1 protein is known to be involved in the regulation of TGF-β signaling in the brain, and studies have shown that overexpression of PDLIM1 can promote the development of neurodegenerative diseases, including Alzheimer's disease.

The Wnt pathway is also a critical pathway that is involved in the development and maintenance of neural stem cells and their differentiated derivatives. The PDLIM1 protein is known to be involved in the regulation of Wnt signaling in the brain, and studies have shown that alterations in PDLIM1 levels or function can affect the stem cell pool and contribute to the development of neurodegenerative diseases.

The Notch pathway is a critical pathway that is involved in the development and regulation of neural stem cells and their differentiated derivatives. The PDLIM1 protein is known to be involved in the regulation of Notch signaling in the brain, and studies have shown that alterations in PDLIM1 levels or function can affect the stem cell pool and contribute to the development of neurodegenerative diseases.

In conclusion, PDLIM1 is a protein that is involved in the regulation of several cellular signaling pathways that are critical for the development and progression of neurodegenerative diseases. The PDLIM1 protein is a potential drug target and may be a valuable biomarker for the diagnosis and treatment of neurodegenerative diseases. Further research is needed to fully understand the role of PDLIM1 in neurodegenerative diseases and to develop effective therapies that target this protein.

Protein Name: PDZ And LIM Domain 1

Functions: Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity)

The "PDLIM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PDLIM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets