Target Name: NUMBL
NCBI ID: G9253
Review Report on NUMBL Target / Biomarker Content of Review Report on NUMBL Target / Biomarker
NUMBL
Other Name(s): Numb-like protein (isoform a) | NBL | TNRC23 | CAG3A | Numb (Drosophila) homolog-like | NUMB-R | Numb-related protein | NUMBR | NUMBL_HUMAN | numb-related protein | Numb-like protein | CTG3a | NUMBLIKE | NUMB like endocytic adaptor protein | numb homolog-like | NUMBL variant 1 | NUMB like endocytic adaptor protein, transcript variant 1 | Numb-R

NUMBL: A Tubulin-like Protein That Regulates Mitosis and Cell Cycle

Numb-like protein (ISOform A), also known as NUMBL, is a protein that is expressed in various tissues throughout the body. It is characterized by its unique molecular structure, which is similar to that of tubulin, a protein found in the cytoskeleton . The special properties of this structure allow NUMBL to play an important role in cell biology.

NUMBL is a non-coding RNA protein whose coding gene is located on the human chromosome. NUMBL plays an important role in the cell cycle and is a component of cell spindle microtubules. The molecular structure of NUMBL is highly similar to tubulin, which makes NUMBL considered a tubulin-like protein (TLP). TLP is a protein ubiquitous in various organisms, and its functions include supporting the assembly and deassembly of spindle microtubules during cell division and participating in mitosis during the cell cycle.

The function of NUMBL in mitosis mainly involves two aspects: first, as a component of spindle microtubules, and second, as a regulator of cell cycle. In mitosis, NUMBL interacts with tubulin 2 (MP2) and tubulin 1 (MP1), proteins that make up the basic structure of microtubules. By interacting with MP2 and MP1, NUMBL can affect the morphological stability and plasticity of microtubules, thereby playing a key role in the progression of mitosis.

NUMBL is also involved in the regulation of the cell cycle. In the S phase of the cell cycle, NUMBL binds to DNA and can affect the DNA transcription process. In addition, NUMBL can also interact with other proteins in the cell cycle, such as with the cyclin Kap118, which can affect the progression of the cell cycle.

As a protein that plays an important role in the cell cycle, NUMBL has attracted widespread attention from scientists. Due to NUMBL's key role in the cell cycle, many researchers have attempted to use it as a drug target or biomarker. Currently, some studies have explored the role of NUMBL in treating cancer, such as inhibiting the activity of NUMBL to inhibit the assembly of spindle microtubules in cancer cells, thereby inhibiting the mitosis of cancer cells. In addition, the interaction between NUMBL and the tumor microenvironment and the role of NUMBL in tumorigenesis were also studied.

As a protein that plays an important role in the cell cycle, NUMBL has broad application prospects. Future studies will continue to explore the biological functions of NUMBL and its role in treating cancer. NUMBL may also become a potential drug target or biomarker, providing new ideas and methods for treating cancer.

Protein Name: NUMB Like Endocytic Adaptor Protein

Functions: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons

The "NUMBL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUMBL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

NUP107 | Nup107-160 complex | NUP133 | NUP153 | NUP155 | NUP160 | NUP188 | NUP205 | NUP210 | NUP210L | NUP210P1 | NUP210P2 | NUP214 | NUP35 | NUP37 | NUP42 | NUP43 | NUP50 | NUP50-DT | NUP54 | NUP58 | NUP62 | NUP62CL | NUP85 | NUP88 | NUP93 | NUP98 | NUPR1 | NUPR2 | NUS1 | NUS1P1 | NUS1P3 | NUSAP1 | NUTF2 | NUTF2P4 | NUTM1 | NUTM2A | NUTM2A-AS1 | NUTM2B | NUTM2B-AS1 | NUTM2D | NUTM2E | NUTM2F | NUTM2G | NVL | NWD1 | NWD2 | NXF1 | NXF2 | NXF3 | NXF4 | NXF5 | NXN | NXNL1 | NXNL2 | NXPE1 | NXPE2 | NXPE3 | NXPE4 | NXPH1 | NXPH2 | NXPH3 | NXPH4 | NXT1 | NXT2 | NXTAR | NYAP1 | NYAP2 | NYNRIN | NYX | OACYLP | OAF | OARD1 | OAS1 | OAS2 | OAS3 | OASL | OAT | OATP1 | OAZ1 | OAZ2 | OAZ3 | OBI1 | OBI1-AS1 | OBP2A | OBP2B | OBSCN | OBSCN-AS1 | OBSL1 | OC90 | OCA2 | OCEL1 | OCIAD1 | OCIAD2 | OCLM | OCLN | OCLNP1 | OCM | OCM2 | OCRL