TAOK2: A Potent Drug Target for Angiotensin System and Cancer Treatment

Target Name: TAOK2

NCBI ID: G9344

TAOK2

TAOK2: A Potent Drug Target for Angiotensin System and Cancer Treatment

TAOK2 (Transient Activator of Angiotensin II with Kallikrein-Induced Apoptosis) is a protein that is expressed in various tissues and cells in the body. It is a potent activator of angiotensin II, a hormone that plays a critical role in blood pressure, inflammation, and pain signaling. TAOK2 has also been shown to induce apoptosis (programmed cell death) in various cell types, including cancer cells.

The potential drug target for TAOK2 is the angiotensin system, which is a complex hormonal system that regulates blood pressure, blood volume, and inflammation in the body. TAOK2 has been shown to interact with the angiotensin system and to contribute to the development of various cardiovascular and kidney diseases.

One of the key mechanisms by which TAOK2 contributes to the angiotensin system is by activating the angiotensin receptor, a protein that is expressed in various tissues and cells in the body. When the angiotensin receptor is activated, it triggers a series of downstream signaling pathways that ultimately result in the production of angiotensin II.

TAOK2 has been shown to induce apoptosis in various cell types, including cancer cells. This suggests that it may be an effective drug target for cancer treatment. By inhibiting TAOK2 activity, doctors can control tumor growth and spread.

Another mechanism by which TAOK2 contributes to the angiotensin system is by regulating the production of various pro-inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6. These cytokines play a critical role in the regulation of inflammation and potential immune responses.TAOK2 has been shown to decrease the production of these cytokines, which may have implications for the treatment of inflammatory diseases.

In addition to its effects on the angiotensin system, TAOK2 has also been shown to have a variety of other effects on various cell types and tissues in the body. For example, it has been shown to contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. It may also be involved in the regulation of fetal development and growth.

Overall, TAOK2 is a promising drug target for the treatment of various diseases, including cancer, cardiovascular disease, and neurodegenerative diseases. Further research is needed to fully understand the effects of TAOK2 and to develop safe and effective treatments.

Protein Name: TAO Kinase 2

Functions: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation

The "TAOK2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAOK2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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