GFAP: A Protein At The Center of Cellular Biology (G2670)
GFAP: A Protein At The Center of Cellular Biology
GFAP (Gli protein kinase coupled receptor) is a protein that is expressed in various tissues and cells in the body. It is a key regulator of cell growth and differentiation, and is involved in the development and maintenance of neural tissues.
GFAP is a transmembrane protein that is characterized by its extracellular domain, which is composed of a catalytic tyrosine kinase. This domain is responsible for the protein's ability to catalyze the phosphate orylation of tyrosine residues on neighboring protein molecules, which is a hallmark of GFAP's catalytic activity.
GFAP is involved in a wide range of cellular processes, including cell growth, differentiation, and survival. It is a potent regulator of cell proliferation, and is required for the development and maintenance of neural tissues, including neurons and glial cells.
GFAP is also involved in the regulation of cell-cell interactions and in the development of tissues that line other tissues, such as the blood vessels and the epithelial tissue.
In addition to its role in cellular biology, GFAP is also a potential drug target. Researchers have identified several GFAP-interactive compounds that have been shown to be effective in treating various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.
One of the most promising of these compounds is a small molecule called GFAP-targeting agent 1 (GTA), which is currently being investigated as a potential therapeutic for the treatment of neurodegenerative diseases. GTA is a potent inhibitor of GFAP, and has been shown to protect against the neurotoxicity caused by various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
Another promising GFAP-targeting compound is a peptide called ANG-302, which is currently being investigated as a potential therapeutic for the treatment of cancer. ANG-302 is a monoclonal antibody that targets GFAP and has been shown to inhibit the growth of various cancers. cell lines in cell culture.
In addition to these compounds, researchers are also studying the potential clinical applications of GFAP as a drug target. GFAP has been shown to be involved in the development of various diseases, including neurodegenerative diseases, and it is possible that GFAP-targeting compounds may be effective in treating these conditions.
GFAP is also being investigated as a potential biomarker for the diagnosis and prognosis of various diseases. Its expression has been shown to be elevated in a variety of tissues and conditions, including neurodegenerative diseases, and it is possible that its levels may be used as a diagnostic or predictive marker for these conditions.
Overall, GFAP is a complex and important protein that is involved in a wide range of cellular processes in the body. Its function as a regulator of cell growth and differentiation makes it an attractive target for the development of new therapeutic compounds, and its potential as a drug or biomarker makes it a promising area of 鈥嬧?媟esearch.
Protein Name: Glial Fibrillary Acidic Protein
Functions: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells
The "GFAP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GFAP comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
GFER | GFI1 | GFI1B | GFM1 | GFM2 | GFOD1 | GFOD2 | GFPT1 | GFPT2 | GFRA1 | GFRA2 | GFRA3 | GFRA4 | GFRAL | GFUS | GGA1 | GGA2 | GGA3 | GGACT | GGCT | GGCX | GGH | GGN | GGNBP1 | GGNBP2 | GGPS1 | GGT1 | GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2
