GFRA2: Key Protein in Neural Development and Function (G2675)
GFRA2: Key Protein in Neural Development and Function
GFRA2 (G protein-coupled receptor alpha-2) is a protein that is expressed in many tissues throughout the body. It is a member of the G protein-coupled receptor family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling. GFRA2 is one of the most well-studied members of this family, and its function in various physiological processes has been extensively characterized.
One of the key functions of GFRA2 is its role in neural development and function. GFRA2 is expressed in the nervous system and is involved in the development, organization, and function of various neural circuits. It is involved in the regulation of neural stem cell proliferation and the formation of neuronal connections. GFRA2 is also involved in the regulation of neurotransmitter release and cell signaling, which are critical processes in the development and maintenance of neural circuits.
GFRA2 has also been shown to play a key role in the regulation of pain and inflammation. It is involved in the regulation of pain perception and the modulation of pain modalities. GFRA2 is also involved in the regulation of inflammation, both in the context of neuroinflammation and in the regulation of immune responses.
GFRA2 has also been shown to be involved in the regulation of cellular metabolism and homeostasis. It is involved in the regulation of glucose metabolism and the modulation of cellular stress responses. GFRA2 is also involved in the regulation of ion channels and neurotransmitter release, which are critical processes in the regulation of cellular homeostasis.
In addition to its involvement in neural development and function, GFRA2 is also known to be involved in a variety of other physiological processes. It is involved in the regulation of sleep-wake cycles, circadian rhythms, and other biological rhythms. GFRA2 is also involved in the regulation of appetite and metabolism, and is thought to play a role in the development of obesity. GFRA2 is also involved in the regulation of body temperature and is thought to play a role in the regulation of thermoregulation.
GFRA2 is also a potential drug target and biomarker for a variety of diseases. For example, GFRA2 has been shown to be involved in the regulation of pain, both in the context of neuroinflammation and in the regulation of pain perception. GFRA2 has also been shown to be involved in the regulation of anxiety and depression, and is thought to play a role in the development of these conditions. GFRA2 is also involved in the regulation of cognitive function and has been shown to play a role in the development of various neurological conditions, including Alzheimer's disease.
In conclusion, GFRA2 is a well-studied protein that is involved in a variety of physiological processes. Its function in neural development and function, as well as its involvement in pain, inflammation, cellular metabolism, and other processes, makes it an attractive target for drug development and research. Further research is needed to fully understand the role of GFRA2 in these processes and to develop effective therapies for the treatment of diseases associated with its dysfunction.
Protein Name: GDNF Family Receptor Alpha 2
Functions: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor
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More Common Targets
GFRA3 | GFRA4 | GFRAL | GFUS | GGA1 | GGA2 | GGA3 | GGACT | GGCT | GGCX | GGH | GGN | GGNBP1 | GGNBP2 | GGPS1 | GGT1 | GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2 | GK3 | GK5 | GKAP1 | GKN1 | GKN2 | GKN3P | GLA | GLB1 | GLB1L | GLB1L2 | GLB1L3
