Target Name: GFI1
NCBI ID: G2672
Review Report on GFI1 Target / Biomarker Content of Review Report on GFI1 Target / Biomarker
GFI1
Other Name(s): growth factor independence-1 | FLJ94509 | Zinc finger protein 163 | zinc finger protein 163 | Growth factor independent protein 1 | Growth factor independent 1 transcriptional repressor, transcript variant 1 | GFI-1 | GFI1A | GFI1_HUMAN | GFI1 variant 1 | growth factor independent 1 transcription repressor | growth factor independent 1 transcriptional repressor | Zinc finger protein Gfi-1 | ZNF163 | SCN2 | growth factor independent protein 1 | Growth factor independence-1

Understanding GFI1: Key Regulator of Cell Growth and Death

GFI1 (growth factor independence-1) is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell growth and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders. Despite its importance, little is known about GFI1 and its function in these contexts.

One of the key challenges in studying GFI1 is its complex biochemical interactions. GFI1 is a protein that is expressed in a wide variety of tissues, including blood vessels, tissues, and organs. It is involved in many different signaling pathways and is thought to be involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and survival.

GFI1 is a protein that is expressed in many different tissues throughout the body, including the brain, heart, liver, and blood vessels. It is also expressed in various cell types, including muscle cells, nerve cells, and epithelial cells. GFI1 is thought to be involved in the regulation of cellular processes that are important for tissue growth and development, as well as the regulation of cell survival and reproduction.

One of the key functions of GFI1 is its role in the regulation of cell growth. GFI1 is known to play a key role in the regulation of cell proliferation, as well as the regulation of cell differentiation. It is thought to do this by regulating the activity of several different signaling pathways, including the TGF-β pathway and the Wnt pathway. These signaling pathways are important for the regulation of cell growth, and changes in their activity can have a significant impact on the growth and development of cells.

Another function of GFI1 is its role in the regulation of cell death. GFI1 is known to play a key role in the regulation of cell apoptosis, which is the process by which cells die and are removed from the body. It is thought to do this by regulating the activity of several different signaling pathways, including the Bcl-2 pathway and the p53 pathway. These signaling pathways are important for the regulation of cell survival and death, and changes in their activity can have a significant impact on the survival and proliferation of cells.

GFI1 is also thought to be involved in the regulation of cellular processes that are important for tissue development and homeostasis. For example, GFI1 is known to play a key role in the regulation of cell migration, which is the movement of cells to different parts of the body. It is also thought to be involved in the regulation of several different signaling pathways that are important for the development and maintenance of tissues and organs.

In addition to its role in the regulation of cellular processes, GFI1 is also thought to be involved in the regulation of cellular interactions. For example, GFI1 is known to play a key role in the regulation of cell-cell interactions, as well as the regulation of cell-tissue interactions. These interactions are important for the regulation of cellular behavior and the development of tissues and organs.

Despite its importance, much is still not known about GFI1 and its function in these contexts. Further research is needed to fully understand the role of GFI1 in cellular processes and its potential as a drug target or biomarker.

Protein Name: Growth Factor Independent 1 Transcriptional Repressor

Functions: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells

The "GFI1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GFI1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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