PLCB4: A Potential Drug Target and Biomarker (G5332)

Target Name: PLCB4

NCBI ID: G5332

PLCB4

PLCB4: A Potential Drug Target and Biomarker

Platelet-derived neurotrophic factor (PDGF) is a protein that plays a crucial role in the development and maintenance of neural tissues, including brain. PDGF has been shown to promote the survival and proliferation of neural cells, and is involved in a wide range of physiological processes, including neural development, differentiation, and regeneration. PDGF has also been implicated in various neurological and psychiatric disorders, making it an attractive target for drug development. One potential drug target for PDGF is PLCB4, a protein that has been shown to interact with PDGF in various contexts.

PLCB4 is a protein that is expressed in many different tissues, including brain, heart, and kidneys. It is a member of the PLC family of proteins, which are known for their ability to mediate various cellular processes, including cell signaling, DNA replication, and cell adhesion. PLCB4 is characterized by a long N-terminus that is involved in several different cellular processes, including cell adhesion, migration, and invasion.

One of the most interesting aspects of PLCB4 is its ability to interact with PDGF. PDGF is a cytoplasmic protein that is involved in promoting the survival and proliferation of various cell types, including neural cells. PLCB4 has been shown to interact with PDGF in various contexts, including in the regulation of neural cell survival and in the development of neural tissues.

One of the key functions of PLCB4 is its role in the regulation of PDGF signaling. PLCB4 has been shown to play a negative role in the regulation of PDGF signaling by promoting the degradation of PDGF. This is done through a process called tyrosination, which is the covalent addition of a tyrosine molecule to a protein. In the case of PLCB4, tyrosination of its C-terminus has been shown to inhibit the ability of PDGF to bind to its receptors, thereby inhibiting the signaling pathway that is responsible for promoting neural cell survival.

Another function of PLCB4 is its role in the regulation of cell adhesion. PLCB4 has been shown to play a positive role in the regulation of cell adhesion by promoting the formation of tight junctions between adjacent cells. This is done through the interaction of PLCB4 with a protein called E-cadherin, which is a transmembrane protein that is involved in cell adhesion.

In addition to its role in the regulation of PDGF signaling and cell adhesion, PLCB4 has also been shown to play a role in the regulation of neural development and differentiation. PLCB4 has been shown to promote the survival and proliferation of neural progenitor cells, which are cells that have the potential to develop into fully developed neural cells. This is done through the regulation of the Wnt signaling pathway, which is a pathway that is involved in the regulation of cell proliferation and differentiation.

Finally, PLCB4 has also been shown to be involved in the regulation of inflammation. PLCB4 has been shown to play a positive role in the regulation of inflammation by promoting the recruitment of immune cells to sites of injury or infection. This is done through the interaction of PLCB4 with a protein called ICAM-1, which is a type of immune cell that is involved in inflammation.

In conclusion, PLCB4 is a protein that has been shown to interact with PDGF in various contexts. Its role in the regulation of PDGF signaling, cell adhesion, neural development and differentiation, and inflammation makes it an attractive target for drug development. Further research is needed to fully understand the mechanisms of PLCB4's role in these processes and to determine its potential as a drug target.

Protein Name: Phospholipase C Beta 4

Functions: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction

The "PLCB4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLCB4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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