Phospholipase C-delta-3: A Potential Drug Target for Cell Signaling and Stress

Target Name: PLCD3

NCBI ID: G113026

PLCD3

Phospholipase C-delta-3: A Potential Drug Target for Cell Signaling and Stress

Phospholipase C-delta-3 (PLCD3) is a protein that is expressed in various cell types, including neurons, endothelial cells, and epithelial cells. It is a potent enzyme that is involved in the breaking down of phospholipids, which are the major components of cell membranes. This process is essential for the functioning of cells, and it is dynamically regulated to maintain the integrity of the cell membrane.

PLCD3 is a key enzyme in the phospholipase C family, which is involved in the regulation of various cellular processes, including cell signaling, inflammation, and stress responses. It is composed of a catalytic active site, a regulatory domain, and a catalytic subdomain. The catalytic active site is the region of the protein that is responsible for catalyzing the breakdown of phospholipids, while the regulatory domain is responsible for regulating the activity of the enzyme. The catalytic subdomain is the region that interacts with other proteins to regulate the activity of PLCD3.

PLCD3 is involved in the regulation of various cellular processes, including the breaking down of phospholipids.

One of the key functions of PLCD3 is its role in the regulation of cell signaling. Phospholipases are involved in the regulation of intracellular signaling pathways, and PLCD3 is no exception. It is involved in the regulation of various signaling pathways, including the TGF-β pathway, the Wnt pathway, and the Hedgehog pathway.

In addition to its role in cell signaling, PLCD3 is also involved in the regulation of inflammation and stress responses. Phospholipases are involved in the production of pro-inflammatory cytokines, such as TNF-伪, IL-1, and IL-6. PLCD3 is also involved in the regulation of cellular stress responses, including the regulation of cell cycle progression and the production of reactive oxygen species (ROS).

PLCD3 is a potential drug target for various diseases, including cancer, cardiovascular disease, and neurodegenerative diseases. Its involvement in the regulation of cell signaling and stress responses makes it an attractive target for small molecules that can modulate its activity. In addition, its role in the regulation of phospholipids makes it an attractive target for compounds that can modulate the levels of phospholipids in cells.

The regulation of PLCD3 activity is controlled by various factors, including its expression level, its localization to specific cellular compartments, and its interaction with other proteins. PLCD3 is highly expressed in various tissues and cells, including neurons, endothelial cells, and epithelial cells. It is predominantly located in the cytoplasm of these cells and can be localized to the endoplasmic reticulum (ER) and the nuclear membrane (NM).

PLCD3 is also known to interact with various proteins, including other phospholipases, transcription factors, and signaling proteins. These interactions play a crucial role in the regulation of PLCD3 activity and the regulation of cellular processes. For example, PLCD3 has been shown to interact with the transcription factor NF-kappa-B and to regulate its activity.

In conclusion, PLCD3 is a protein that is involved in the regulation of various cellular processes, including cell signaling, inflammation, and stress responses. Its activity is regulated by various factors, including its expression level, localization to specific cellular compartments, and interaction with other proteins. As a result, PLCD3 is an attractive target for small molecules that can modulate its activity. Further research is needed to fully understand the regulation of PLCD3 activity and its potential as a drug target.

Protein Name: Phospholipase C Delta 3

Functions: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity)

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•   general information;
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•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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