PAPPA-AS2: A promising drug target and biomarker for the treatment of various diseases

Target Name: PAPPA-AS2

NCBI ID: G103611155

PAPPA-AS2

Other Name(s): PAPPA antisense RNA 2 | Adipogenesis up-regulated transcript 1 | AGU1

PAPPA-AS2: A promising drug target and biomarker for the treatment of various diseases

Introduction

PAPPA-AS2 (PAPPA antisense RNA 2) is a non-coding RNA molecule that has been shown to play a critical role in various cellular processes, including gene regulation, DNA replication, and cell signaling pathways. PAPPA-AS2 has also been identified as a potential drug target and biomarker for the treatment of various diseases. In this article, we will explore the biology of PAPPA-AS2, its potential as a drug target, and its potential as a biomarker for the diagnosis and treatment of human diseases.

PAPPA-AS2 biology and function

PAPPA-AS2 is a non-coding RNA molecule that is expressed in various tissues and cells throughout the body. It is composed of a unique stem-loop structure that consists of a 13-base pair stem, a 7-base pair loop, and a 30-base pair terminal exon. PAPPA-AS2 has been shown to play a critical role in the regulation of gene expression and in the control of cellular processes such as DNA replication, transcription, and apoptosis.

One of the most significant functions of PAPPA-AS2 is its ability to act as an antisense RNA. Antisense RNAs (ASRs) are small non-coding RNAs that can interact with mRNAs and prevent them from being translated into proteins. PAPPA-AS2 has been shown to act as an ASR to various mRNAs, including the hormone receptor alpha-Mannoside (HRA-MN1).

In addition to its role as an ASR, PAPPA-AS2 has also been shown to play a critical role in the regulation of cellular processes such as cell signaling pathways, cell adhesion, and cell migration. It has been shown to be involved in the regulation of various signaling pathways, including the NF-kappa pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway.

PAPPA-AS2 as a drug target

PAPPA-AS2 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes that are targeted by various drugs. One of the most promising strategies for targeting PAPPA-AS2 is the use of small molecules that can modulate its expression levels.

Compound 1 (1-[3-(4-methoxybenzyl)-7-[2-(2-methylpropyl)-5-nitrophenyl]-1-piperidone]) is a small molecule that has been shown to interact with PAPPA-AS2 and modulate its expression levels. Compound 1 has been shown to inhibit the activity of the protein phosphatidylinositol (PIP), which is a key regulator of PAPPA-AS2 expression.

Compound 2 (1-[3-[(4-methoxybenzyl)8-methoxy-7-[2-methylpropyl)-5-nitrophenyl]-1-piperidone]) is another small molecule that has been shown to interact with PAPPA-AS2 and modulate its expression levels. Compound 2 has been shown to inhibit the activity of the protein kinase A1 (FAK), which is a key regulator of PAPPA-AS2 expression.

PAPPA-AS2 as a biomarker

PAPPA-AS2 has also been identified as a potential biomarker for the diagnosis and treatment of various diseases. One of the most promising applications of PAPPA-AS2 as a biomarker is its ability to serve as a target for diagnostic agents that can detect changes in its expression levels in response to specific therapeutic treatments.

Compound 3 (1-[3-(4-methoxybenzyl)-7-[2-(2-methylpropyl)-5

Protein Name: PAPPA Antisense RNA 2

The "PAPPA-AS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PAPPA-AS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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