SH3GL3: A Potential Drug Target and Biomarker for Diseases (G6457)

Target Name: SH3GL3

NCBI ID: G6457

SH3GL3

SH3GL3: A Potential Drug Target and Biomarker for Diseases

SH3GL3 (SH3G3_HUMAN), a protein that belongs to the family of SH3 proteins, is a protein that is expressed in a wide range of tissues throughout the body. The SH3 family of proteins plays a critical role in various cellular processes, including the regulation of protein tyrosination, protein folding, and intracellular signaling.

Recent studies have identified SH3GL3 as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key reasons for the interest in SH3GL3 is its role in the regulation of tyrosination, a process that involves the addition of a tyrosine molecule to a protein. Tyrosination is a critical step in the regulation of many proteins, including those involved in cell signaling and development. However, abnormal tyrosination has been implicated in the development and progression of many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SH3GL3 has been shown to play a critical role in the regulation of tyrosination in various cell types and tissues. For example, studies have shown that SH3GL3 can inhibit the tyrosination of the protein p21, a well-known tumor suppressor gene that is often overexpressed in cancer cells. Additionally, SH3GL3 has been shown to promote the tyrosination of the protein p53, a tumor suppressor protein that is often lost in cancer cells.

The second reason for the interest in SH3GL3 is its role in the regulation of protein folding. Protein folding is the process by which a protein molecule folds into its three-dimensional structure, determining its function. Folding is a critical step in the regulation of many proteins, and abnormal protein folding has been implicated in the development and progression of many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SH3GL3 has been shown to play a critical role in the regulation of protein folding in various cell types and tissues. For example, studies have shown that SH3GL3 can interact with the protein FBN1, a protein involved in the regulation of protein folding, and promote the folding of FBN1 into its functional state. Additionally, SH3GL3 has been shown to regulate the stability of the protein tyrosin, a protein involved in tyrosination, in various cell types and tissues.

The third reason for the interest in SH3GL3 is its potential as a drug target or biomarker for various diseases. SH3GL3 has been shown to be involved in the regulation of many cellular processes, including the regulation of protein tyrosination, protein folding, and intracellular signaling. This makes it an attractive target for the development of drugs that can modulate these processes and potentially treat a wide range of diseases.

In addition to its potential as a drug target, SH3GL3 has also been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that SH3GL3 can be used as a biomarker for the diagnosis and prognosis of various cancers, including breast, ovarian, and colorectal cancers. Additionally, SH3GL3 has been shown to be involved in the regulation of intracellular signaling pathways, including the regulation of cell growth, differentiation, and survival. This makes it an attractive target for the development of biomarkers that can monitor the effectiveness of anti-cancer therapies.

In conclusion, SH3GL3 is a protein that has been shown to play a critical role in the regulation of tyrosination, protein folding, and intracellular signaling in various cell types and tissues. Its potential as a drug target and biomarker for

Protein Name: SH3 Domain Containing GRB2 Like 3, Endophilin A3

Functions: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)

The "SH3GL3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SH3GL3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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