SH3BP4: A Potential Drug Target and Biomarker (G23677)

Target Name: SH3BP4

NCBI ID: G23677

SH3BP4

SH3BP4: A Potential Drug Target and Biomarker

SH3BP4, also known as SH3BP4-ALZH, is a protein that is expressed in various tissues and cells in the human body. It is a member of the SH3BP4 family, which is known for its role in protein-protein interactions and regulation of cellular signaling pathways. The SH3BP4 gene has four exons, and its corresponding transcript has one exon.

SH3BP4 has been shown to play a critical role in the regulation of several cellular processes, including cell signaling, cell adhesion, and inflammation. It is a key regulator of the T-cell receptor (TCR), which is a critical receptor for T-cell development, activation, and function.

In addition to its role in TCR regulation, SH3BP4 has also been shown to play a critical role in the regulation of CD47, a protein that is involved in the development and function of hematopoietic stem cells (HSCs). CD47 is a protein that is expressed in the bone marrow and other tissues, and it is known for its role in the development and survival of HSCs.

SH3BP4 has also been shown to play a critical role in the regulation of theNotch signaling pathway, which is a critical pathway involved in the regulation of cellular signaling pathways, including stem cell self-renewal and differentiation.

In addition to its role in cellular signaling pathways, SH3BP4 has also been shown to play a critical role in the regulation of inflammation. It is a key regulator of the NF-kappa-B signaling pathway, which is involved in the regulation of inflammation and immune responses.

Given its role in multiple cellular processes, SH3BP4 has potential as a drug target or biomarker. Researchers have shown that SH3BP4 can be targeted with small molecules, such as inhibitors, to inhibit its function in these processes. In addition, SH3BP4 has been shown to be involved in several diseases, including cancer, autoimmune diseases, and inflammation.

In conclusion, SH3BP4 is a protein that has been shown to play a critical role in multiple cellular processes, including TCR regulation, CD47 regulation, Notch signaling pathway regulation, and inflammation. Given its potential as a drug target or biomarker, researchers are actively working to develop inhibitors or other compounds that can inhibit its function in these processes. Further research is needed to fully understand the role of SH3BP4 in these processes and to develop effective treatments for SH3BP4-related diseases.

Protein Name: SH3 Domain Binding Protein 4

Functions: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy

The "SH3BP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SH3BP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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