SH3BP5: A Potential Drug Target and Biomarker (G9467)

Target Name: SH3BP5

NCBI ID: G9467

SH3BP5

SH3BP5: A Potential Drug Target and Biomarker

SH3BP5 (SH3 domain-binding protein 5 (isoform a)) is a protein that is expressed in various tissues and cell types in the human body. It is a member of the SH3BP family, which includes proteins that play a critical role in the regulation of protein stability and dynamics. In recent years, researchers have become increasingly interested in SH3BP5 due to its potential as a drug target or biomarker.

The SH3BP5 protein is composed of 215 amino acid residues and has a calculated molecular mass of 21.9 kDa. It is expressed in various tissues, including the brain, heart, liver, and kidney. SH3BP5 is primarily localized to the endoplasmic reticulum (ER) and nuclear membrane, and is also found in the cytoplasm.

SH3BP5 functions as a protein that can interact with various protein partners, including other SH3BP5 proteins and non-SH3BP5 proteins. One of its most well-studied functions is its role in the regulation of protein stability and dynamics. SH3BP5 has been shown to interact with several protein partners, including the protein PSD1 (p21), which is a G protein-coupled receptor (GPCR) that is involved in the regulation of many cellular processes, including cell growth, differentiation, and survival.

Additionally, SH3BP5 has been shown to interact with the protein SHC1 (sc-receptin 1), which is a non-coding RNA-protein hybrid that has been shown to play a role in the regulation of gene expression and cellular processes. The interaction between SH3BP5 and SHC1 has been shown to promote the stability of SHC1, a protein that is involved in the regulation of many cellular processes, including cell growth, differentiation, and survival.

In addition to its role in protein stability and dynamics, SH3BP5 has also been shown to play a critical role in the regulation of cellular processes that are important for the development and progression of diseases. For example, SH3BP5 has been shown to be involved in the regulation of cell migration, a critical process that is involved in the development of many diseases, including cancer.

In conclusion, SH3BP5 is a protein that has been shown to play a critical role in the regulation of protein stability and dynamics, as well as in the regulation of cellular processes that are important for the development and progression of diseases. As a result, SH3BP5 has potential as a drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of SH3BP5 in the regulation of protein stability and dynamics, as well as its potential as a drug target or biomarker.

Protein Name: SH3 Domain Binding Protein 5

Functions: Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death

The "SH3BP5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SH3BP5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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