SH3GL1P2: A Potential Drug Target and Biomarker (G6459)

Target Name: SH3GL1P2

NCBI ID: G6459

SH3GL1P2

Other Name(s): SH3GLP2 | CNSA-P2 | SH3 domain containing GRB2 like 1, endophilin A2 pseudogene 2

SH3GL1P2: A Potential Drug Target and Biomarker

SH3GL1P2, also known as SH3GLP2, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its full name is SH3-glutamyl-Lysine Phosphate 2, and it is a highly conserved non-proteinogenic amino acid (NPA) that has been shown to play a critical role in various physiological processes in the body.

The SH3 family of NPA enzymes is a well-established group of proteins that are involved in a wide range of cellular processes, including cell signaling, protein synthesis, and stress resistance. The SH3 family is characterized by the presence of a characteristic catalytic site that is composed of a conserved catalytic core and a variable catalytic acid side chain. The catalytic core is a parallel beta-sheet that is composed of three beta-strands, while the catalytic acid side chain is a linear or diagonal chain that is rich in amino acids that are involved in catalytic activity.

SH3GL1P2 is a member of the SH3 family of NPA enzymes and is expressed in a variety of tissues, including the brain, heart, and kidneys. It is highly conserved, with a sequence identity of 97% between its amino acid sequence and that of a related protein, SH3-glutamyl-Lysine Phosphate 1 (SH3GLP1).

The functions of SH3GL1P2 are still being fully understood, but it is clear that it plays an important role in various physiological processes. One of the most significant functions of SH3GL1P2 is its role in intracellular signaling. SH3GL1P2 has been shown to play a critical role in the regulation of protein synthesis and to contribute to the negative regulation of cell signaling pathways.

In addition to its role in intracellular signaling, SH3GL1P2 is also involved in the regulation of various physiological processes outside of the cell, including inflammation, fibrosis, and autophagy. It is highly expressed in various tissues and has been shown to play a critical role in the regulation of cellular processes that are associated with aging and diseases, such as Alzheimer's disease, cancer, and cardiovascular disease.

The potential utility of SH3GL1P2 as a drug target is significant, given its involvement in various physiological processes that are associated with aging and diseases. There is a growing interest in developing drugs that can modulate the activity of SH3GL1P2 and improve cellular health and longevity.

In conclusion, SH3GL1P2 is a highly conserved and well-functionalized protein that plays a critical role in various physiological processes in the body. Its potential as a drug target makes it an attractive target for the development of new therapies for a variety of age-related diseases. Further research is needed to fully understand the functions of SH3GL1P2 and to develop effective strategies for modulating its activity.

Protein Name: SH3 Domain Containing GRB2 Like 1, Endophilin A2 Pseudogene 2

The "SH3GL1P2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SH3GL1P2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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