VPS45: A Potential Drug Target and Biomarker (G11311)

Target Name: VPS45

NCBI ID: G11311

VPS45

VPS45: A Potential Drug Target and Biomarker

Vacuolar protein sorting-associated protein 45 (VPS45) is a protein that plays a crucial role in the transport of various proteins into the endoplasmic reticulum (ER) and is essential for the proper functioning of the endoplasmic reticulum. VPS45 is a 22kDa protein that consists of 116 amino acids and has a calculated pI of 9.95. It is located in the endoplasmic reticulum and is involved in the sorting of proteins into different endoplasmic reticulum transmembrane transport vesicles. VPS45 is a potential drug target and biomarker due to its unique function in the ER and its potential role in the development of various diseases.

Disease-Causation Relationships

VPS45 is involved in the delivery of proteins to the endoplasmic reticulum, which plays a crucial role in the regulation of protein function and the development of various diseases. One of the well-known diseases that is associated with VPS45 is the neurodegenerative disorder Alzheimer's disease. Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain.

The accumulation of beta-amyloid plaques is thought to be caused by the misfolding and localization of proteins, including VPS45, into the endoplasmic reticulum. This misfolding and localization of proteins is believed to contribute to the development of neurofibrillary tangles and the formation of beta-amyloid plaques, which are thought to be the hallmark of Alzheimer's disease.

Another potential disease that is associated with VPS45 is the cancer. Cancer is a disease that is characterized by the rapid and uncontrolled growth of cells, and the delivery of proteins to the endoplasmic reticulum is a critical step in the regulation of cell growth and division. However, the misfolding and localization of proteins, including VPS45, have been implicated in the development and progression of cancer.

Potential Therapeutic Strategies

The misfolding and localization of proteins, including VPS45, into the endoplasmic reticulum is a known risk factor for the development of various diseases, including Alzheimer's disease and cancer. Therefore, strategies to target VPS45 and prevent its misfolding and localization have the potential to be therapeutic strategies for the treatment of these diseases.

One potential therapeutic strategy is the use of small molecules that can inhibit the activity of VPS45. These small molecules can be used to treat diseases associated with VPS45, such as Alzheimer's disease and cancer. For example, a small molecule called 1-butyl-4-piperidone (BPI) has been shown to inhibit the activity of VPS45 and prevent its misfolding and localization in the ER.

Another potential therapeutic strategy is the use of antibodies that can specifically target VPS45 and prevent its localization to the endoplasmic reticulum. These antibodies can be used to treat diseases associated with VPS45, such as Alzheimer's disease and cancer. For example, an antibody called A42 has been shown to block the localization of VPS45 to the endoplasmic reticulum and prevent its misfolding and localization in the ER.

Conclusion

Vacuolar protein sorting-associated protein 45 (VPS45) is a protein that plays a crucial role in the transport of various proteins into the endoplasmic reticulum and is essential for the proper functioning of the endoplasmic reticulum. VPS45 is a potential drug target and biomarker due to its unique function in the ER and its potential role in the development of various diseases, including Alzheimer's disease and cancer. The misfolding and localization of proteins, including VPS45, have

Protein Name: Vacuolar Protein Sorting 45 Homolog

Functions: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network

The "VPS45 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VPS45 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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