Target Name: VWA5B2
NCBI ID: G90113
Review Report on VWA5B2 Target / Biomarker Content of Review Report on VWA5B2 Target / Biomarker
VWA5B2
Other Name(s): VWA5B2 variant 1 | Von Willebrand factor A domain containing 5B2, transcript variant 1 | VW5B2_HUMAN | Von Willebrand factor A domain-containing protein 5B2 (isoform 1) | von Willebrand factor A domain-containing protein 5B2 | von Willebrand factor A domain containing 5B2

VWA5B2: A Potential Drug Target and Biomarker

VWA5B2, also known as VWA5B2 variant 1, is a protein that is expressed in various tissues and cells in the body. Its exact function is not yet fully understood, but research has shown that it plays a role in the development and progression of various diseases, including cancer. As a result, VWA5B2 has become a focus of interest for researchers as a potential drug target or biomarker.

The identification and characterization of VWA5B2 as a potential drug target comes from a study by the Kim lab at the University of California, Irvine. In this study, the researchers used a technique called RNA sequencing to identify differentially expressed genes in cancer tissues relative to normal tissues. They found that VWA5B2 was significantly downregulated in cancer tissues, and that its levels were positively correlated with the expression of the oncogene PDCD1.

Furthermore, the researchers found that overexpressing VWA5B2 in cancer cells led to an increase in cell motility and a decrease in the invasion and metastasis of cancer cells. These findings suggest that VWA5B2 may have a negative impact on the progression of cancer, and that it may be a useful target for cancer therapies.

As a potential biomarker, VWA5B2 has been studied in a variety of settings. For instance, the same Kim lab study also found that VWA5B2 was downregulated in human tissue samples from various types of cancer, including breast, lung, and colorectal cancer. Additionally, the researchers found that VWA5B2 was positively correlated with the expression of the cancer-associated protein PDCD1. These findings suggest that VWA5B2 may be a useful biomarker for cancer diagnosis and treatment.

In addition to its potential as a drug target and biomarker, VWA5B2 is also of interest due to its structural biology. The Kim lab study used a technique called nuclear magnetic resonance to determine the structure of VWA5B2 in its unbound form. The results showed that VWA5B2 had a distinct N-terminal domain and a C-terminal region that was involved in its stability and interactions with other proteins.

Overall, the characterization of VWA5B2 as a potential drug target and biomarker has significant implications for the development of new cancer therapies. Further research is needed to fully understand its function and to determine its effectiveness as a therapeutic target. However, the potential of VWA5B2 as a drug and biomarker is a promising area of research that may lead to new and more effective treatments for cancer.

Protein Name: Von Willebrand Factor A Domain Containing 5B2

The "VWA5B2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VWA5B2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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