Target Name: WBP11
NCBI ID: G51729
Review Report on WBP11 Target / Biomarker Content of Review Report on WBP11 Target / Biomarker
WBP11
Other Name(s): WW domain binding protein 11 | BUG13 | PPP1R165 | Splicing factor, PQBP1 and PP1 interacting | FAP90 | Npw38-binding protein NpwBP | CFAP90 | Splicing factor that interacts with PQBP-1 and PP1 | splicing factor, PQBP1 and PP1 interacting | VCTERL | Npw38-binding protein | SIPP1 | VCTRL | splicing factor that interacts with PQBP-1 and PP1 | SH3 domain-binding protein SNP70 | WW domain-binding protein 11 | protein phosphatase 1, regulatory subunit 165 | WBP11_HUMAN | WBP-11 | NPWBP | NpwBP | DKFZp779M1063

Targeting WBP11 for Cancer and Neurodegenerative Diseases

WBP11, a protein known as the WW domain binding protein 11, is a key regulator of the Wnt signaling pathway in various organisms, including humans. This pathway plays a crucial role in the development, maintenance, and progression of various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, targeting WBP11 as a drug or biomarker has significant implications for the treatment of these diseases.

WBP11: Structure and Function

WBP11 is a 22-kDa protein that is expressed in various tissues, including liver, lung, brain, and muscle. Its name comes from its unique structure, which consists of a long N-terminal region containing a singleWW domain, a short C-terminal region containing a GFP-like gene, and a unique N-terminal region that contains a farnesylated cysteine residue.

The WW domain is a well-known protein-coding domain that is found in various proteins, including WBP11. This domain is known for its ability to interact with other proteins through a variety of mechanisms, such as sequence-specificity, structural similarity, and electrostatic interactions. In WBP11, the WW domain interacts with the protein N-terminal transmembrane domain (TMD) of the protein Pyh1, which is a key regulator of the Wnt signaling pathway.

The C-terminal region of WBP11 contains a GFP-like gene, which encodes a protein that can be used as a cell-specific marker or to track the expression of the protein in various tissues. The N-terminal region of WBP11 contains a farnesylated cysteine residue, which is known for its role in protein stability and modification.

WBP11 in Disease

WBP11 has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its involvement in these diseases has been attributed to its role in the regulation of the Wnt signaling pathway, which is a critical pathway in the development and maintenance of these diseases.

WBP11 is known to be involved in the regulation of cell proliferation, differentiation, and survival. In cancer, WBP11 has been shown to play a role in the regulation of cell cycle progression, apoptosis, and angiogenesis. For example, studies have shown that high levels of WBP11 are associated with poor prognosis in breast cancer patients.

WBP11 has also been implicated in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Studies have shown that decreased levels of WBP11 are associated with the development of these diseases. Additionally, WBP11 has been shown to play a role in the regulation of development, including embryonic development and tissue repair.

WBP11 as a Drug or Biomarker

targeting WBP11 as a drug or biomarker has significant implications for the treatment of various diseases. If approved, drugs that target WBP11 may have efficacy in treating cancer, neurodegenerative diseases, and developmental disorders.

One approach to targeting WBP11 is to use small molecules that can modulate its activity. For example, inhibitors of the WBP11 WW domain have been shown to be effective in reducing the activity of the protein in cell culture models of cancer. These inhibitors may be useful in preventing the development of cancer or in treating cancer cells that are resistant to traditional therapies.

Another approach to targeting WBP11 is to use antibodies that can specifically recognize and label the protein. These antibodies may be used to diagnose diseases associated with WBP11, such as cancer, neurodegenerative diseases, or developmental disorders.

Conclusion

WBP11 is a protein that has significant implications for the treatment of various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its involvement in the regulation of the Wnt signaling pathway makes it an attractive target for small molecules and antibodies. Further research is needed to fully understand the role of WBP11 in these diseases and to develop effective treatments.

Protein Name: WW Domain Binding Protein 11

Functions: Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity

The "WBP11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WBP11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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