Target Name: WASHC5
NCBI ID: G9897
Review Report on WASHC5 Target / Biomarker Content of Review Report on WASHC5 Target / Biomarker
WASHC5
Other Name(s): MGC111053 | WASH complex subunit strumpellin | RTSC1 | RTSC | WASH complex subunit 5 (isoform 1) | Strumpellin | SPG8 | WASC5_HUMAN | Spastic paraplegia 8 (autosomal dominant) | WASH complex subunit 5 | WASH complex subunit 5, transcript variant 1 | strumpellin | KIAA0196 | WASHC5 variant 1

WashC5: A Protein Targeted in Cancer, Neurodegenerative Diseases and Autoimmune Disorders

WashC5, also known as MGC111053, is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and liver. It is a member of the washing cycle gene family, which includes proteins that are involved in the regulation of intracellular signaling pathways.

Recent studies have identified WashC5 as a potential drug target in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because WashC5 has been shown to play a role in the regulation of cellular processes that are important for the development and progression of these diseases.

One of the key mechanisms by which WashC5 is involved in the development of cancer is its role in the regulation of cell signaling pathways that promote the growth and survival of cancer cells. Studies have shown that WashC5 can inhibit the activity of several signaling pathways that are important for cancer cell growth, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway.

In addition to its role in cancer development, WashC5 has also been shown to be involved in the regulation of neurodegenerative diseases. This is because WashC5 has been shown to play a role in the regulation of the production of neurotransmitters, which are important for the function of nerve cells.

Another potential mechanism by which WashC5 is involved in the development of autoimmune disorders is its role in the regulation of the immune system. Studies have shown that WashC5 can inhibit the activity of several signaling pathways that are important for the regulation of the immune response, including the TLR signaling pathway and the NF-kappa-B pathway.

In conclusion, WashC5 is a protein that has been identified as a potential drug target in several diseases. Its role in the regulation of cellular processes that are important for the development and progression of these diseases makes it an attractive target for drug development. Further research is needed to fully understand the mechanisms by which WashC5 is involved in the development of cancer, neurodegenerative diseases, and autoimmune disorders.

Protein Name: WASH Complex Subunit 5

Functions: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666)

The "WASHC5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WASHC5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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WASIR1 | WASL | WAVE1 complex | WBP1 | WBP11 | WBP11P1 | WBP1L | WBP2 | WBP2NL | WBP4 | WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2