WASH2P: A Protein Implicated in Cell Adhesion, Migration and Signaling Pathways
WASH2P: A Protein Implicated in Cell Adhesion, Migration and Signaling Pathways
WASH2P is a protein that belongs to the WASP family homolog 2 (WASP2) gene. It is a cytoplasmic protein that is expressed in various cell types of the human body, including blood cells, epithelial cells, and nervous cells. WASH2P is known to play a role in various cellular processes, including cell adhesion, migration, and signaling pathways.
The WASP family homolog 2 (WASP2) gene is a member of the WASP2 gene family, which is characterized by the presence of a single intron and a single exon in the 5'-end region of the gene. The WASP2 gene is located on chromosome 18q21 and has been implicated in various cellular processes, including cell adhesion, migration, and signaling pathways.
WASH2P is a 120-amino acid protein that is expressed in various cell types of the human body. It has a molecular weight of 17.4 kDa and a calculated pI of 6.3. WASH2P is a cytoplasmic protein that is expressed in the cytoplasm of various cell types, including blood cells, epithelial cells, and nervous cells. It is involved in various cellular processes, including cell adhesion, migration, and signaling pathways.
WASH2P has been shown to play a role in various signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway. TGF-β is a cytokine that is involved in cell growth, differentiation, and signaling pathways. WASH2P has been shown to be involved in the regulation of TGF-β signaling pathway by interacting with the transcription factor, SMAD2.
WASH2P has also been shown to play a role in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. WASH2P is involved in the regulation of cell adhesion by interacting with the adhesion molecule, E-cadherin.
WASH2P has also been shown to play a role in the regulation of cell migration. Cell migration is the process by which cells move from one location to another in the body. WASH2P is involved in the regulation of cell migration by interacting with the migration protein, 伪-actinin.
In conclusion, WASH2P is a protein that has been shown to play a role in various cellular processes, including cell adhesion, migration, and signaling pathways. As a result, it may be a drug target or biomarker for various diseases. Further research is needed to fully understand the role of WASH2P in cellular processes and its potential as a drug target or biomarker.
Protein Name: WASP Family Homolog 2, Pseudogene
Functions: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity)
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• expression level;
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More Common Targets
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