Target Name: VWA8
NCBI ID: G23078
Review Report on VWA8 Target / Biomarker Content of Review Report on VWA8 Target / Biomarker
VWA8
Other Name(s): P7BP2 | von Willebrand factor A domain-containing protein 8 | Von Willebrand factor A domain-containing protein 8 precursor (isoform b) | VWA8 variant 1 | KIAA0564 | Von Willebrand factor A domain containing 8, transcript variant 1 | VWA8_HUMAN | von Willebrand factor A domain containing 8 | PEX7-binding protein 2 | Pex7p-binding protein 2

VWA8: A Potential Drug Target for Cancer

VWA8 (P7BP2), a protein located in the endoplasmic reticulum (ER), has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and subcellular localization in the ER make it an attractive target for small molecules and antibodies.

The ER is a transmembrane system, which spans the length of the cell and functions as a sorting station for various proteins. It is responsible for importing and processing proteins from the cytoplasm into the cell surface. The ER is also the site of protein degradation and modulation, which makes it a crucial hub for the regulation of cellular processes.

VWA8 is a member of the P7 family of proteins, which are involved in the ER retention and localization of various proteins. P7 proteins localize to the ER through their C-terminus, which contains a unique acidic amino acid sequence known as P7 conserved domain (P7 domain). The P7 domain is involved in the formation of a hydrophobic core, which draws water into the ER and facilitates protein recruitment.

VWA8 is a 21 kDa protein that localizes to the end of the long arm (L) of the P7 protein. It has a unique structure, with a long N-terminus and a C-terminus that is involved in the formation of a hydrophobic core . VWA8 is also known as P7BP2 due to its interaction with the P7 protein. The P7BP2 domain is responsible for the protein's stability and localization to the ER.

In cancer, the P7BP2 protein has been shown to be overexpressed or mutated in various tissues, including breast, ovarian, and prostate cancer cells. Overexpression of VWA8 has been shown to promote the growth and survival of cancer cells, while mutations in the P7BP2 domain have been linked to the development of cancer stem cells and the failure of cancer therapies.

The potential drug targets for VWA8 include the inhibition of its phosphorylation at its Serine-29 residue, which is known to play a role in the regulation of protein stability and localization. Additionally, the inhibition of the interaction between VWA8 and the P7 protein has been shown to be a potential strategy for cancer treatment.

In conclusion, VWA8 is a protein with great potential as a drug target and biomarker for various diseases, including cancer. Its unique localization to the ER and its involvement in the regulation of protein stability and localization make it an attractive target for small molecules and antibodies . Further studies are needed to fully understand the role of VWA8 in disease progression and the development of new cancer therapies.

Protein Name: Von Willebrand Factor A Domain Containing 8

Functions: Exhibits ATPase activity in vitro

The "VWA8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VWA8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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