Target Name: WBP4
NCBI ID: G11193
Review Report on WBP4 Target / Biomarker Content of Review Report on WBP4 Target / Biomarker
WBP4
Other Name(s): WW domain-binding protein 4 | Formin-binding protein 21 | WW domain binding protein 4 | WW domain-containing-binding protein 4 | WBP4_HUMAN | formin binding protein 21 | FBP21 | domain-containing binding protein 4 | WBP-4 | FNBP21 | WW domain-containing binding protein 4 | Domain-containing binding protein 4 | MGC117310 | Formin binding protein 21

WBP4: A Potential Drug Target and Biomarker for Various Diseases

WBP4, also known as WW domain-binding protein 4, is a protein that is expressed in various tissues throughout the body. It plays a crucial role in the regulation of cell growth, differentiation, and survival. The WBP4 protein has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

WBP4: Structure and Function

WBP4 is a 21-kDa protein that is composed of 215 amino acid residues. It has a unique structure that consists of a long N-terminus, a middle transmembrane region, and an C-terminus. The N-terminus of WBP4 contains a putative N-endonuclease domain, which is responsible for domain-binding to various DNA sequences. The middle transmembrane region contains several putative transmembrane domains, including a T-cell receptor (TCR) domain, a G-protein-coupled receptor (GPCR) domain, and a leucine-rich repeat (LRR) domain. The C-terminus of WBP4 contains a singleton domain and a variable region.

WBP4 is primarily expressed in various tissues, including the brain, spinal cord, heart, liver, and muscle. It is also expressed in the placenta, which suggests that it may be involved in fetal development and growth. WBP4 has been shown to localize to the endoplasmic reticulum (ER) and to be involved in the regulation of DNA binding and gene expression.

WBP4 as a Drug Target

WBP4 has been identified as a potential drug target due to its unique structure and function. The N-endonuclease domain of WBP4 has been shown to interact with various DNA sequences, including those found in cancer-causing viruses, such as the herpes simplex virus 2 (HSV2). This suggests that WBP4 may be involved in the regulation of DNA damage and the development of cancer.

In addition, the TCR domain of WBP4 has been shown to interact with the protein PD-L1, which is a negative regulator of immune responses. This interaction suggests that WBP4 may be involved in the regulation of immune responses and the development of autoimmune disorders.

The GPCR domain of WBP4 has been shown to interact with the protein FAK, which is involved in cell adhesion, migration, and invasion. This interaction suggests that WBP4 may be involved in the regulation of cell-cell interactions and the development of neurodegenerative diseases.

The LRR domain of WBP4 has been shown to interact with the protein HDACs, which are proteins that are involved in the regulation of DNA binding. This interaction suggests that WBP4 may be involved in the regulation of DNA binding and the development of various diseases, including cancer.

WBP4 as a Biomarker

WBP4 has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The expression of WBP4 has been shown to be increased in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

For example, studies have shown that the expression of WBP4 is increased in various types of cancer, including breast, lung, and colorectal cancer. This increase in expression may be due to the regulation of DNA binding and gene expression by WBP4.

In addition, studies have shown that the expression of WBP4 is increased in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. This increase in expression may be due to the regulation of DNA binding and gene expression by WBP4.

Finally, studies have shown that the expression of WBP4 is increased in autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. This increase in expression may be due to the regulation of DNA binding and gene expression by WBP4.

Conclusion

WBP4 is a protein that is expressed in various tissues throughout the body and has been identified as a potential drug target and biomarker for various diseases. The unique structure and function of WBP4, including the N-endonuclease domain, the TCR domain, the GPCR domain, and the LRR domain, suggest that it may be involved in the regulation of DNA binding and gene expression. The potential drug target and biomarker properties of WBP4 make it an attractive target for future research. Further studies are needed to fully understand its role in the regulation of DNA binding and gene expression and its potential as a drug target and biomarker.

Protein Name: WW Domain Binding Protein 4

Functions: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750)

The "WBP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WBP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3