VPS8: A Protein with Potential as A Drug Target (G23355)

Target Name: VPS8

NCBI ID: G23355

VPS8

VPS8: A Protein with Potential as A Drug Target

VPS8 (VPS8_HUMAN) is a protein that is expressed in various tissues of the human body. It is a member of the voltage-dependent ion channel (V-type) family, which are involved in the regulation of ion traffic in cells. One of the unique features of VPS8 is its ability to form voltage-dependent ion channels that are highly selective for certain ions, such as calcium (Ca2+) and magnesium (Mg2+). These channels play a crucial role in the regulation of various cellular processes, including muscle contractions, nerve function, and brain activity.

The research on VPS8 has been primarily focused on its potential drug-related applications. Several studies have shown that VPS8 is involved in a wide range of physiological processes that are highly relevant to human health, including the regulation of muscle function, the effects of pain on the nervous system, and the modulation of neurotransmitter release. As a result, VPS8 has been identified as a promising drug target for a variety of neurological and psychiatric disorders.

One of the key benefits of VPS8 as a drug target is its ability to modulate the activity of other proteins. This is accomplished through the formation of complex between VPS8 and its ligands, which can then alter the activity of these other proteins. For example, research has shown that VPS8 can form a complex with the protein known as TRPV4, which is involved in the regulation of pain perception. By modulating TRPV4 activity, VPS8 can effectively reduce the intensity of pain that is felt by the body.

Another potential benefit of VPS8 as a drug target is its ability to modulate the activity of ion channels that are involved in the regulation of various physiological processes. For example, VPS8 has been shown to play a role in the regulation of the activity of the sodium (Na+) and calcium (Ca2+) channels, which are involved in the regulation of muscle contractions and nerve function. By modulating these channels, VPS8 can effectively alter the activity of these channels, leading to changes in cellular processes.

In addition to its potential role as a drug target, VPS8 has also been shown to have a wide range of potential applications in other fields. For example, the regulation of ion traffic by VPS8 is involved in the function of many different tissues and organs, including the brain, heart, and muscle. This means that changes in VPS8 activity could have a significant impact on the function of these tissues, including their ability to function properly.

Overall, VPS8 (VPS8_HUMAN) is a protein that has the potential to be a drug target for a variety of neurological and psychiatric disorders. Its unique ability to form voltage-dependent ion channels and its involvement in the regulation of various physiological processes make it an attractive target for researchers and clinicians alike. Further research is needed to fully understand the role of VPS8 in human health and to develop effective treatments for the disorders that are associated with its dysfunction.

Protein Name: VPS8 Subunit Of CORVET Complex

Functions: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290)

The "VPS8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VPS8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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