Target Name: WASHC3
NCBI ID: G51019
Review Report on WASHC3 Target / Biomarker Content of Review Report on WASHC3 Target / Biomarker
WASHC3
Other Name(s): coiled-coil domain-containing protein 53 | coiled-coil domain containing 53 | WASH complex subunit 3 | WASH complex subunit 3 (isoform 1) | WASH complex subunit 3, transcript variant 1 | WASH complex subunit CCDC53 | WASC3_HUMAN | Coiled-coil domain-containing protein 53 | WASHC3 variant 1 | CGI-116 | CCDC53

Washc3: A Protein Involved in Various Cellular Processes and Diseases

Washc3, also known as coiled-coil domain-containing protein 53, is a protein that plays a crucial role in various biological processes in the cell. It is a highly conserved protein that can be found in various organisms, including humans. washc3 is known to be involved in various cellular processes, including cell signaling, DNA replication, and repair, among others.

The washing-coil domain is a unique feature of washc3 that gives it its name. This domain is composed of 125 amino acid residues and is responsible for the protein's stability and localization in the cell. The washing-coil domain is involved in the formation of a stable complex with the nucleosome, which is the basic unit of chromatin. This interaction between the protein and the nucleosome is important for the regulation of DNA replication, repair, and other cellular processes.

In addition to its role in cell signaling and DNA replication, washc3 is also involved in the regulation of cell apoptosis, which is the process of cell death. Apoptosis is a natural process that helps the body eliminate damaged or dysfunctional cells. However, in some diseases, such as cancer, the process of apoptosis becomes abnormal and can lead to the growth and progression of the disease.

Washc3 has also been shown to be involved in the regulation of cell migration, which is the movement of cells towards specific locations in the body. This process is important for the development and maintenance of tissues and organs, and is also involved in the regulation of cancer cell invasion and metastasis.

The genetic variation in washc3 has been identified, and some studies have suggested that variations in the gene may be associated with various diseases, including cancer. For example, studies have shown that individuals with certain genetic variations, such as those in the TP53 gene, may have an increased risk of developing cancer.

In conclusion, washc3 is a protein that plays a crucial role in various cellular processes in the cell. Its washing-coil domain, which is responsible for the protein's stability and localization in the cell, is involved in the regulation of cell signaling, DNA replication, repair, apoptosis, and cell migration. The genetic variation in washc3 has been identified, and some studies have suggested that variations in the gene may be associated with various diseases, including cancer. Therefore, washc3 may be a drug target or biomarker for the development of new treatments for these diseases.

Protein Name: WASH Complex Subunit 3

Functions: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting

The "WASHC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WASHC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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WASHC4 | WASHC5 | WASIR1 | WASL | WAVE1 complex | WBP1 | WBP11 | WBP11P1 | WBP1L | WBP2 | WBP2NL | WBP4 | WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9