WASH3P: A Pseudogene with Potential as A Drug Target and Biomarker
WASH3P: A Pseudogene with Potential as A Drug Target and Biomarker
WASH3P is a pseudogene, which means it is a non-coding RNA molecule that has a functional role in gene expression. It is a member of the WASP family, which is known for their role in regulating gene expression and cell signaling pathways. This family of RNA molecules is also known as the PRISM complex.
The WASP family plays a crucial role in the regulation of various cellular processes, including cell signaling pathways, cell growth, and apoptosis. WASP family homologs (WASP3, WASP4, and WASP5) have been shown to play a significant role in these processes.
WASH3P is a member of the WASP family homolog 3 (WASP3) family. It is a non-coding RNA molecule that has been shown to play a role in the regulation of gene expression. Studies have shown that WASP3 is involved in the regulation of various cellular processes, including cell signaling pathways, cell growth, and apoptosis.
Drug Target Potential
WASH3P has the potential to be a drug target due to its involvement in various cellular processes. Its involvement in cell signaling pathways and cell growth make it a potential target for small molecules or antibodies that can modulate its activity. Additionally, its role in apoptosis makes it a potential target for drugs that can induce or inhibit apoptosis.
WASP3 has also been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels are formed. This suggests that it may be a potential target for drugs that can modulate angiogenesis.
Biomarker Potential
WASH3P has the potential to be used as a biomarker for various diseases. Its involvement in the regulation of cell signaling pathways and cell growth makes it a potential biomarker for diseases that are characterized by the regulation of these processes, such as cancer, neurodegenerative diseases, and cardiovascular diseases.
Additionally, its role in the regulation of apoptosis makes it a potential biomarker for diseases that are characterized by the regulation of apoptosis, such as neurodegenerative diseases and cancer.
Conclusion
WASH3P is a pseudogene that is involved in the regulation of various cellular processes, including cell signaling pathways, cell growth, and apoptosis. Its potential as a drug target and biomarker make it an attractive target for small molecules or antibodies that can modulate its activity. Further research is needed to fully understand the role of WASP3 in these processes and its potential as a drug target and biomarker.
Protein Name: WASP Family Homolog 3, Pseudogene
Functions: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity)
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• general information;
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• protein biological mechanisms;
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• expression level;
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More Common Targets
WASH4P | WASH5P | WASH6P | WASH7P | WASH8P | WASHC1 | WASHC2A | WASHC2C | WASHC3 | WASHC4 | WASHC5 | WASIR1 | WASL | WAVE1 complex | WBP1 | WBP11 | WBP11P1 | WBP1L | WBP2 | WBP2NL | WBP4 | WDCP | WDFY1 | WDFY2 | WDFY3 | WDFY3-AS2 | WDFY4 | WDHD1 | WDPCP | WDR1 | WDR11 | WDR11-DT | WDR12 | WDR13 | WDR17 | WDR18 | WDR19 | WDR20 | WDR24 | WDR25 | WDR26 | WDR27 | WDR3 | WDR31 | WDR33 | WDR35 | WDR35-DT | WDR36 | WDR37 | WDR38 | WDR4 | WDR41 | WDR43 | WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11
