ACAP3: A Protein with Potential as A Drug Target (G116983)

Target Name: ACAP3

NCBI ID: G116983

ACAP3

ACAP3: A Protein with Potential as A Drug Target

ACAP3 (also known as CENTB5) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the Tetraspanin family, which are a group of non-coding RNAs that play a central role in various cellular processes.

One of the defining features of ACAP3 is its unique structure. It is a 21-kDa protein that consists of a 156 amino acid chain that is held together by 15 non-covalent bonds. The protein is composed of two distinct domains: an N- terminal domain that contains a single amino acid at positions 1-20, and a C-terminal domain that contains a series of amino acids at positions 21-64.

The N-terminal domain of ACAP3 is rich in conserved sequences Asp-20, Asp-21, Asp-22, Asp-23, Asp-24, Asp-25, Asp-26, Asp-27, Asp-28, Asp -29, Asp-30, and Asp-31. These conserved sequences are involved in the protein's stability and interactions with other proteins.

The C-terminal domain of ACAP3 is also of interest because it contains a unique genetic variation called a missense mutation. This mutation, which occurred at position 42, results in the substitution of a glutamic acid for a lysine. This substitution has been shown to have a significant impact on the protein's stability and function.

ACAP3 is a protein that has been identified as a potential drug target in a variety of diseases. For example, ACAP3 has been shown to be involved in the regulation of stem cell proliferation and the development of cancer. It has also been shown to be involved in the regulation of pain perception and the modulation of neurotransmitter release in the brain.

In addition to its potential drug-targeting properties, ACAP3 is also a valuable biomarker for a variety of diseases. For example, ACAP3 has been shown to be elevated in the blood of individuals with certain types of cancer, and it has been used as a biomarker to predict the outcomes of certain types of cancer treatments.

Overall, ACAP3 is a protein that continues to be of interest to researchers due to its unique structure and function. Its potential as a drug target and biomarker make it an important target for further study.

Protein Name: ArfGAP With Coiled-coil, Ankyrin Repeat And PH Domains 3

Functions: GTPase-activating protein for the ADP ribosylation factor family

The "ACAP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ACAP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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