GPC: Enzyme Involved in DNA Replication and Cellular Signaling Pathways

Target Name: LACC1

NCBI ID: G144811

LACC1

Other Name(s): Guanosine phosphorylase LACC1 | JUVAR | laccase (multicopper oxidoreductase) domain containing 1 | Laccase domain containing 1, transcript variant 1 | Laccase domain containing 1, transcript variant 6

GPC: Enzyme Involved in DNA Replication and Cellular Signaling Pathways

Guanosine phosphorylase (GPC) is a enzyme involved in the metabolism of guanosine, a nucleotide base that is important for various cellular processes. LACC1 (Guanosine Phosphorylase LACC1) is a protein that is specific for GPC and is expressed in various tissues and cells in the body. The role of GPC in cellular processes is wide-ranging and includes the regulation of cell signaling pathways, DNA replication, and chromatin structure.

GPC is a critical enzyme in the DNA replication process. During DNA replication, GPC is involved in the production of new DNA strands, which are then separated and used to create two daughter copies of the double helix. GPC activity is essential for the initiation of DNA replication and is critical for the formation of a stable double helix.

In addition to its role in DNA replication, GPC is also involved in the regulation of cell signaling pathways. GPC has been shown to be involved in the regulation of cell proliferation, differentiation, and apoptosis. GPC has been shown to play a role in the regulation of cell cycle progression, and it has been shown to be involved in the regulation of apoptosis.

GPC is also involved in the regulation of chromatin structure. GPC has been shown to play a role in the regulation of chromatin structure and has been shown to be involved in the regulation of gene expression. GPC has been shown to interact with histone proteins, which are the proteins that make up the nucleosome, the basic unit of chromatin.

GPC has also been shown to be involved in the regulation of cell signaling pathways. GPC has been shown to play a role in the regulation of cell signaling pathways, including the regulation of neurotransmitter signaling, insulin signaling, and angiotensin signaling.

GPC is a protein that is expressed in various tissues and cells in the body. GPC has been shown to be involved in the regulation of various cellular processes, including cell signaling pathways, DNA replication, and chromatin structure. As a result, GPC is a potential drug target or biomarker for a variety of diseases.

GPC has been shown to be involved in the development of various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, GPC has been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. GPC has also been shown to be involved in the development of cardiovascular diseases, including heart failure and hypertension.

In addition to its potential role in the development of neurodegenerative and cardiovascular diseases, GPC is also a potential drug target or biomarker for a variety of other diseases. For example, GPC has been shown to be involved in the regulation of cancer cell growth and has been shown to play a role in the development of certain types of cancer. GPC has also been shown to be involved in the regulation of inflammation, and has been shown to play a role in the development of certain types of inflammatory diseases.

GPC is a protein that is involved in a wide range of cellular processes in the body. Its role in these processes is essential for the regulation of various cellular processes, including cell signaling pathways, DNA replication, and chromatin structure. As a result, GPC is a potential drug target or biomarker for a variety of diseases and should be further studied in order to understand its role in these processes and its potential as a therapeutic agent.

Protein Name: Laccase Domain Containing 1

Functions: Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (PubMed:31978345). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345). Also has adenosine deaminase activity (PubMed:31978345). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (PubMed:28593945, PubMed:31875558). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (PubMed:31875558). Does not show laccase activity (PubMed:27959965, PubMed:31978345)

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