HTR1B Related Diseases

HTR1B

Related Diseases

1) Epilepsy, Generalized
Epilepsy, Idiopathic Generalized, also known as idiopathic generalized epilepsy, is related to epilepsy, idiopathic generalized 5 and generalized epilepsy with febrile seizures plus, type 7, and has symptoms including seizures, non-epileptic convulsion and absence seizures. An important gene associated with Epilepsy, Idiopathic Generalized is GABRA1 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1), and among its related pathways/superpathways are "Celecoxib Pathway, Pharmacodynamics" and "Benzodiazepine Pathway, Pharmacodynamics". The drugs Levetiracetam and Valproic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and eye, and related phenotypes are eeg with spike-wave complexes (>3.5 hz) and bilateral tonic-clonic seizure

2) Migraine
Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine without aura, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Migraine with or Without Aura 1 is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Type II diabetes mellitus and Cellular roles of Anthrax toxin. The drugs Mineral oil and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and cortex, and related phenotypes are photophobia and vomiting

3) Hypoglycemia
Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 2 and hypoglycemia, leucine-induced, and has symptoms including sugar craving An important gene associated with Hypoglycemia is ABCC8 (ATP Binding Cassette Subfamily C Member 8), and among its related pathways/superpathways are Metabolism and PI3K-Akt signaling pathway. The drugs Pasireotide and Insulin aspart have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and heart, and related phenotypes are no effect and no effect

4) Stroke
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

5) Major Depression
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

6) Cluster Headache
Cluster Headache, also known as headache, cluster, is related to headache and trigeminal neuralgia, and has symptoms including headache and recurrent paroxysmal headache. An important gene associated with Cluster Headache is HCRTR2 (Hypocretin Receptor 2), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Zolmitriptan and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and brain.

7) Restless Legs Syndrome
Restless Legs Syndrome, also known as restless leg syndrome, is related to restless legs syndrome 7 and restless legs syndrome 6, and has symptoms including back pain, headache and pain. An important gene associated with Restless Legs Syndrome is RLS4 (Restless Legs Syndrome 4), and among its related pathways/superpathways are Alpha-synuclein signaling and "Methylphenidate Pathway, Pharmacodynamics". The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and spinal cord.

8) Narcolepsy
Narcolepsy, also known as narcoleptic syndrome, is related to narcolepsy 1 and cerebellar ataxia, deafness, and narcolepsy, autosomal dominant, and has symptoms including hemiplegia, sleep disturbances and snoring. An important gene associated with Narcolepsy is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are Transcription factor regulation in adipogenesis and Orexin receptor pathway. The drugs Central Nervous System Stimulants and Sodium citrate have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye.

9) Headache
Headache, also known as headache disorder, is related to cluster headache and migraine without aura. An important gene associated with Headache is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Nuclear receptors meta-pathway and Development Ligand-independent activation of ESR1 and ESR2. The drugs Galantamine and Crofelemer have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and brain, and related phenotypes are no effect and no effect

10) Nicotine Dependence
Smoking As a Quantitative Trait Locus 3, also known as lung cancer susceptibility 2, is related to tobacco addiction and substance dependence. An important gene associated with Smoking As a Quantitative Trait Locus 3 is CHRNA3 (Cholinergic Receptor Nicotinic Alpha 3 Subunit), and among its related pathways/superpathways are Transmission across Chemical Synapses and Postsynaptic nicotinic acetylcholine receptors. The drugs Naltrexone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and prefrontal cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

11) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

12) Obsessive-compulsive Disorder
Obsessive-Compulsive Disorder, also known as ocd, is related to trichotillomania and gilles de la tourette syndrome, and has symptoms including sleep disturbances, photophobia and psychiatric symptom. An important gene associated with Obsessive-Compulsive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Ethanol and Cycloserine have been mentioned in the context of this disorder. Affiliated tissues include brain, subthalamic nucleus and caudate nucleus, and related phenotypes are anxiety and obsessive-compulsive behavior

13) Dysthymia
Dysthymic Disorder, also known as dysthymia, is related to obsessive-compulsive personality disorder and migraine without aura. An important gene associated with Dysthymic Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Sertraline and Testosterone undecanoate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and temporal lobe, and related phenotypes are nervous system and homeostasis/metabolism

14) Mood Disorder
Mood Disorder, also known as mood disorders, is related to major depressive disorder and schizoaffective disorder, and has symptoms including alexithymia and psychiatric symptom. An important gene associated with Mood Disorder is DISC2 (Disrupted In Schizophrenia 2), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Lithium carbonate and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related phenotypes are nervous system and homeostasis/metabolism

15) Binge Eating Disorder
Bulimia Nervosa, also known as bulimia, is related to abdominal obesity-metabolic syndrome 1 and polysubstance abuse, and has symptoms including salt craving, symptoms and decrease in appetite. An important gene associated with Bulimia Nervosa is BULN (Bulimia Nervosa, Susceptibility To), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Memantine and Sibutramine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, prefrontal cortex and skin, and related phenotypes are bulimia and nervous system

16) Depression
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

17) Heroin Dependence
Heroin Dependence is related to acute stress disorder and morphine dependence. An important gene associated with Heroin Dependence is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Diamorphine and Methadone have been mentioned in the context of this disorder. Affiliated tissues include prefrontal cortex, brain and cortex, and related phenotypes are nervous system and homeostasis/metabolism

18) Anxiety Disorders
Anxiety, also known as anxiety disorders, is related to generalized anxiety disorder and separation anxiety disorder, and has symptoms including nervousness, agitation and feeling tense. An important gene associated with Anxiety is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Amlodipine and Lorazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and thyroid, and related phenotypes are nervous system and normal

19) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

20) Pathological Gambling
Pathological Gambling, also known as compulsive gambling, is related to polysubstance abuse and chronic pain. An important gene associated with Pathological Gambling is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Acamprosate and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include prefrontal cortex, cortex and brain, and related phenotypes are no effect and no effect

21) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

22) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

23) Sleep Disorder
Sleep Disorder, also known as sleep disorders, is related to narcolepsy 1 and idiopathic hypersomnia, and has symptoms including back pain, cachexia and cyanosis. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are IL-9 Signaling Pathways and Peptide hormone metabolism. The drugs Tramadol and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are no effect and no effect

24) Anorexia Nervosa
Anorexia Nervosa, also known as anorexia nervosa, susceptibility to, is related to eating disorder and body dysmorphic disorder, and has symptoms including decrease in appetite An important gene associated with Anorexia Nervosa is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are GPCR downstream signalling and Signal Transduction. The drugs Aripiprazole and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and prefrontal cortex, and related phenotypes are Reduced mammosphere formation and nervous system

25) Schizophrenia
Schizophrenia, also known as schizophrenia with or without an affective disorder, is related to schizoaffective disorder and psychotic disorder, and has symptoms including sleep disturbances, photophobia and personality changes. An important gene associated with Schizophrenia is RTN4R (Reticulon 4 Receptor), and among its related pathways/superpathways are "Methylphenidate Pathway, Pharmacodynamics" and MTHFR deficiency. The drugs Molindone and Asenapine have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are eeg abnormality and hallucinations

26) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

27) Mitochondrial Disease
Mitochondrial Disease, also known as mitochondrial diseases, is related to mitochondrial metabolism disease and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. An important gene associated with Mitochondrial Disease is MT-ATP6 (Mitochondrially Encoded ATP Synthase Membrane Subunit 6), and among its related pathways/superpathways are "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." and Complex I biogenesis. The drugs Atorvastatin and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include placenta, skeletal muscle and spinal cord.

28) Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and frontotemporal dementia and/or amyotrophic lateral sclerosis 2, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Varenicline and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and brain, and related phenotypes are muscle weakness and dementia

29) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

30) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

31) Gastrointestinal Disorders
Gastrointestinal System Disease, also known as gastrointestinal disease, is related to crohn's disease and stomach disease, and has symptoms including peeling tongue, catarrh and blood in stool. An important gene associated with Gastrointestinal System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. The drugs Indomethacin and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include gastrointestinal tract, small intestine and liver.

32) Autonomic Nervous System Disorders
Autonomic Nervous System Disease, also known as autonomic nervous system dysfunction, is related to autonomic peripheral neuropathy and hyperhidrosis, gustatory, and has symptoms including back pain, constipation and diarrhea. An important gene associated with Autonomic Nervous System Disease is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Cardiac conduction and G-Beta Gamma Signaling. The drugs Moxonidine and Acetylcarnitine have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and medulla oblongata, and related phenotypes are normal and renal/urinary system

33) Autism
Autism, also known as autistic disorder, is related to autism spectrum disorder and attention deficit-hyperactivity disorder. An important gene associated with Autism is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Neuroscience and Pathways affected in adenoid cystic carcinoma. The drugs Acetylcholine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, brain and bone marrow, and related phenotypes are eeg abnormality and increased serum serotonin

34) Nutrition Disorders
Nutritional Deficiency Disease, also known as malnutrition, is related to folic acid deficiency anemia and iron deficiency anemia, and has symptoms including abdominal pain, cachexia and constipation. An important gene associated with Nutritional Deficiency Disease is TTR (Transthyretin), and among its related pathways/superpathways are Metabolism of proteins and Glucose / Energy Metabolism. The drugs Heparin, bovine and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include liver, skeletal muscle and breast, and related phenotypes are no effect and no effect

35) Thrombosis
Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to blood group, cromer system and protein-losing enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and endothelial, and related phenotypes are thrombocytosis and hepatomegaly

36) Speech Disorders
Speech Disorder, also known as speech disorders, is related to stuttering and echolalia, and has symptoms including cluttering, aprosodia and scanning speech. An important gene associated with Speech Disorder is CLCN6 (Chloride Voltage-Gated Channel 6). The drugs Dopamine and Ecopipam have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and subthalamic nucleus, and related phenotypes are no effect and no effect

37) Bipolar Disorder
Bipolar Disorder, also known as depression, bipolar, is related to bipolar i disorder and schizophrenia. An important gene associated with Bipolar Disorder is MAFD1 (Major Affective Disorder 1), and among its related pathways/superpathways are Neurotransmitter clearance and "Methylphenidate Pathway, Pharmacodynamics". The drugs Coal tar and Eleuthero have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

38) Alcoholism
Alcohol Dependence, also known as alcoholism, is related to alcohol use disorder and personality disorder. An important gene associated with Alcohol Dependence is GABRA2 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2), and among its related pathways/superpathways are Transmission across Chemical Synapses and Metapathway biotransformation Phase I and II. The drugs Lenograstim and Alogliptin have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and prefrontal cortex, and related phenotypes are alcoholism and no effect

39) Eating Disorder
Eating Disorder, also known as eating disorders, is related to bulimia nervosa and anorexia nervosa, and has symptoms including decrease in appetite, adipsia and symptoms concerning nutrition, metabolism, and development. An important gene associated with Eating Disorder is GHRL (Ghrelin And Obestatin Prepropeptide), and among its related pathways/superpathways are GPCR downstream signalling and Signal Transduction. The drugs Zinc sulfate and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related phenotypes are Weakly decreased NFAT1-GFP nuclear translocation and homeostasis/metabolism

40) Hyperprolactinemia
Hyperprolactinemia, also known as chiari-frommel syndrome, is related to galactorrhea and pituitary tumors. An important gene associated with Hyperprolactinemia is PRLR (Prolactin Receptor), and among its related pathways/superpathways are TGF-Beta Pathway and GPCR downstream signalling. The drugs Risperidone and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, ovary and bone, and related phenotypes are galactorrhea and oligomenorrhea

41) Hypertension
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure

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