Migraine
About the Disease
Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine without aura, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Migraine with or Without Aura 1 is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Type II diabetes mellitus and Cellular roles of Anthrax toxin. The drugs Mineral oil and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and cortex, and related phenotypes are photophobia and vomiting
Common Targets
G781 | G100533467 | Prostanoid Receptor (nonspecified subtype) | G221692 | G2915 | G10800 | G116 | G3355 | P18508 | G148 | Calcium channel (nonspecified subtype) | G79054 | Kainate Receptor (GluR) (nonspecified subtype) | G9254 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | G10021 | G2100 | G4842 | G254240 | G1132 | Interleukin-1 (nonspecified subtype) | G4885 | G1312 | G1815 | G4128 | G2897 | G3350 | G1268 | G4543 | Tachykinin Receptor (nonspecified subtype) | G9132 | G57604 | Alpha-2 Adrenergic receptors (nonspecified subtype) | G6530 | G4049 | G51230 | G8536 | G1010 | G2905 | G7442 | Lipoxygenase (nonspecified subtype) | G574412 | G2688 | G2908 | G10280 | G63976 | G11343 | G23224 | G1128 | G63826 | Estrogen receptor (nonspecified subtype) | G3065 | P11019 | G4886 | G5742 | G338567 | G3786 | G2566 | G197322 | G2099 | G5241 | G134 | P6320 | G2561 | G105 | G100526693 | G43 | G3105 | G3357 | G3360 | G5443 | G136 | G5024 | G5743 | P40594 | G771 | G1392 | G255239 | G105375655 | G4968 | G6581 | G6753 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | G4524 | Glutamate Transporter (nonspecified subtype) | G6334 | alpha-Adrenoceptor (nonspecified subtype) | G5243 | G729230 | G135 | G3630 | G3776 | G1621 | G246213 | G2898 | G2906 | G2912 | G112476 | G1139 | Opioid receptor (nonspecified subtype) | Sodium channel (nonspecified subtype) | G101927995 | G8743 | G2891 | G222236 | G3787 | Gap junction Connexin ( (nonspecified subtype) | G150 | G5020 | G6536 | G10428 | G9780 | G5054 | G4544 | G51196 | G2917 | G4846 | G57674 | G10267 | G3586 | G7517 | G63982 | G105377986 | G4985 | G4987 | G54207 | G2892 | G3361 | G2068 | G64324 | G6754 | G2903 | G92949 | G5734 | G140 | P3824 | G4209 | G22992 | G6532 | KCNQ Channels (K(v) 7) (nonspecified subtype) | G5025 | G2554 | P5662 | G3831 | G1812 | G2562 | G147700 | G8654 | G148254 | G29954 | G153 | G4311 | G2166 | G8829 | G3062 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | G7466 | G3356 | beta-Adrenoceptor (nonspecified subtype) | G6833 | G796 | G79783 | G2899 | G610 | G27159 | G10203 | G26960 | sigma Receptor (nonspecified subtype) | G4843 | G8989 | P6348 | G4035 | G101927066 | G162514 | G3269 | G80010 | G2690 | G1136 | G5138 | G105378316 | G146 | Dopamine receptor (nonspecified subtype) | G4763 | G26 | G6869 | G185 | G50508 | G460 | L-Type calcium channel (nonspecified subtype) | G154 | G55879 | G3362 | G760 | G117 | G6323 | G7166 | G2548 | G328 | HTR1B | P6321 | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | G7399 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | G623 | P6058 | Histone deacetylase (nonspecified subtype) | G94233 | G27346 | alpha1-Adrenoceptor (nonspecified subtype) | Gastric H+/K+-ATPase | G2697 | G768 | G2911 | P16740 | Cyclooxygenase (COX) (nonspecified subtype) | G7054 | G3576 | G773 | G10093 | G105378525 | G6755 | G3358 | G1588 | G114548 | G5602 | G5731 | G1814 | P24924 | G472 | G41 | G3107 | G3818 | G8645 | Nitric oxide synthase (NOS) (nonspecified subtype) | G5027 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | G747 | Gap Junction Protein (nonspecified subtype) | 5-Hydroxytryptamine Receptor (nonspecified subtype) | Histamine Receptor (HR) (nonspecified subtype) | G744 | G7124 | G2740 | G6531 | Potassium Channels (nonspecified subtype) | G7515 | G6804 | G9290 | G6751 | G5021 | G3736 | G7040 | G2914 | G117194 | Endothelin receptor (nonspecified subtype) | G4129 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | G56128 | Tryptophan 5-Monooxygenase (nonspecified subtype) | NADPH Oxidase (nonspecified subtype) | G57419 | G545 | G3683 | alpha-Amylase (nonspecified subtype) | P10999 | G60495 | G1453 | G23245 | G2564 | G7099 | G2904 | G1129 | G7157 | G4567 | G290 | G56130 | G18 | G2559 | G134864 | G117196 | G105375013 | Glutamate Receptor Ionotropic (nonspecified subtype) | G6506 | G9457 | G3352 | P5859 | G2840 | G3785 | G152 | G3363 | G105377013 | G79987 | G10335 | G10413 | G2556 | G5728 | P6747 | G4988 | G11255 | G627 | G6916 | G9152 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G100616414 | G6326 | Monoamine oxidase (MAO) (nonspecified subtype) | G2073 | G1134 | G327 | G1436 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G1636 | G6870 | G4986 | G1269 | G79800 | G3106 | G9900 | G774 | G6752 | G6865 | G3354 | G400745 | G1813 | G2150
The "Target / Biomarker Review Report" is a comprehensive and customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about the Target(s) / Biomarker(s) of your choice related to Migraine, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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