Hypertension
About the Disease
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure
Common Targets
P18508 | G1 | G5409 | G9536 | G148 | G1187 | G259249 | G5468 | G7276 | G7352 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | G5789 | G23533 | G3294 | cAMP Phosphodiesterase (nonspecified subtype) | P32835 | G6548 | G7150 | G58508 | G3782 | G5028 | G9776 | G5879 | G64078 | G6764 | G116511 | G1312 | P36692 | G139760 | G558 | G59272 | G6571 | G80298 | G1268 | G2053 | G2100 | G83447 | G3350 | G4128 | G716 | G7376 | G22901 | G6530 | G23150 | G51738 | P32836 | G5293 | G89866 | G9943 | Alpha-2 Adrenergic receptors (nonspecified subtype) | G1950 | G7442 | G84876 | G200186 | G1188 | Serine/Threonine Kinase (nonspecified subtype) | G80339 | G2908 | G116512 | G1408 | G1489 | G4543 | G7299 | G8694 | G2864 | G5778 | G6093 | G142 | G29119 | G6778 | G5016 | G3752 | G217 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | G1586 | G406 | G4314 | G5321 | G2784 | G5578 | G11188 | Lipoxygenase (nonspecified subtype) | G151 | G6559 | G183 | G1902 | G4576 | G5733 | G7295 | G763 | G3065 | G91703 | G11093 | G1128 | G5029 | G55105 | G9370 | G5739 | G9817 | G9970 | G3426 | G22937 | G2832 | G5742 | G339768 | G203228 | G598 | Estrogen receptor (nonspecified subtype) | G2099 | G4524 | G23224 | G101927825 | G846 | G105370676 | G3156 | G113026 | G5291 | G9172 | G6656 | G2217 | P11019 | G1589 | G22834 | G759 | G25970 | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | G116519 | P6320 | G4286 | G4886 | G5241 | G5290 | G553 | G5743 | Glycogen phosphorylase (nonspecified subtype) | G43 | G79698 | G79927 | G25890 | G3357 | G134 | G3772 | DNA Topoisomerase II (nonspecified subtype) | G23411 | G3383 | G187 | G239 | G5243 | G283208 | G9429 | G3479 | P6463 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | G191 | G140469 | G8824 | G6296 | G6319 | P40594 | G80895 | G2645 | G100126793 | G136 | G1536 | G1543 | G728434 | G2324 | G54901 | G650 | G5024 | G51393 | G887 | G3360 | G1859 | G100873946 | G8913 | G5880 | Kir 3.1/3.4 | G7357 | G50854 | G8841 | G55107 | G5600 | G132320 | cGMP-Dependent Protein Kinase (nonspecified subtype) | G1956 | G771 | G23327 | G50624 | G8600 | G3290 | Steroid 5-alpha-Reductase (nonspecified subtype) | G2321 | G6446 | P6884 | G4318 | G5137 | G29102 | G116085 | G765 | G4940 | G100048912 | G285973 | G93550 | G5782 | G3630 | G3739 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | G441639 | G4535 | G2671 | G6753 | G801 | G3061 | G11213 | G5152 | G119032 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | G6338 | alpha-Adrenoceptor (nonspecified subtype) | G7046 | G729230 | G5077 | G135 | G6563 | G1621 | G51179 | G5481 | G6850 | G19 | G7421 | G2776 | G1176 | G60676 | G383 | G1803 | G4519 | G2250 | G6648 | G2078 | G2138 | G5030 | G50507 | G5527 | Sodium channel (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | G4158 | G5205 | G2702 | G5467 | G10628 | Cholesterol esterase (nonspecified subtype) | G3758 | G3783 | G2159 | G8698 | G8856 | G1139 | cGMP Phosphdiesterase (PDE) (nonspecified subtype) | G231 | G8942 | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | G3795 | G775 | G4688 | G255738 | G9294 | G2952 | G4773 | G7498 | Opioid receptor (nonspecified subtype) | G6550 | G204010 | G554 | G9356 | G5770 | G10266 | G93974 | G3189 | G150 | G4846 | G590 | G3791 | P16126 | P24881 | G6521 | G2658 | G2932 | G3248 | Guanylate cyclase (nonspecified subtype) | G339896 | G350 | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | G5020 | G3480 | G167691 | G1191 | G367 | G155 | G7412 | G4887 | G5054 | Chloride channel (nonspecified subtype) | G221785 | G127733 | G6300 | G3067 | G632 | G2494 | G10747 | P19243 | Neuromedin U Receptor (nonspecified subtype) | G1910 | G24144 | G2243 | G2316 | G100130207 | G345 | P16176 | G54790 | P6278 | G6943 | G57674 | G836 | G55829 | G65266 | G4689 | G22987 | G23405 | G1066 | G1591 | Adenylate Cyclase (nonspecified subtype) | G4985 | G53345 | G3375 | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | G81624 | G6597 | G4987 | G51422 | G6329 | G81494 | G10267 | G118 | G1511 | G7433 | G5740 | G3553 | Myosin Class II (nonspecified subtype) | G162282 | G4313 | G2837 | Kir 3.1/3.2 | Mitogen-Activated Protein Kinase (nonspecified subtype) | G100 | G2696 | G54986 | G64478 | G1903 | G766 | G65267 | G4159 | G10877 | P34664 | G66005 | G140 | G3569 | G6340 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | G408187 | G219621 | G5166 | G5340 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | Adenosine deaminase (nonspecified subtype) | G6532 | G9140 | G9376 | G5734 | G125 | P5867 | G377677 | G6582 | G4734 | G286046 | G5836 | G3356 | G3934 | G1634 | G2867 | G4316 | G8654 | G10268 | G9620 | G10878 | G6262 | G4878 | G23189 | G2322 | G10847 | G57403 | G338821 | G7422 | G490 | K(ATP) Channel (nonspecified subtype) | G3760 | Na+/K+-ATPase (nonspecified subtype) | G5079 | G3741 | G65268 | G160335 | G7010 | G719 | G2264 | G1577 | G153 | G84517 | G53347 | G5729 | G113263 | 15-Lipoxygenase (nonspecified subtype) | G706 | G4311 | G857 | G3552 | G1812 | G5583 | G23269 | G23365 | G100379251 | G6660 | G6833 | G2185 | G5580 | G571 | G120227 | G4350 | G2166 | G27030 | G3558 | G1994 | G284486 | G3062 | G65125 | G4620 | G4889 | Trypsin (nonspecified subtype) | G164781 | G5034 | G100528007 | beta-Adrenoceptor (nonspecified subtype) | G2194 | G4633 | G2538 | G10060 | G5540 | Elastase (nonspecified subtype) | G132789 | G157273 | G2244 | P6348 | G8989 | G5617 | G57101 | G9821 | G144132 | G2153 | G4843 | G4553 | G51750 | G283748 | G3458 | Prostanoid TP receptor (nonspecified subtype) | G6773 | G4738 | G10203 | G4879 | G53831 | G2868 | G1544 | G3990 | G445 | G3953 | G412 | G5156 | G8876 | G3269 | G3777 | G185 | G51094 | G2878 | sigma Receptor (nonspecified subtype) | G7015 | G219790 | G497258 | G10159 | G356 | Cysteine Protease (nonspecified subtype) | G8792 | G56670 | P11025 | G6335 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | G4052 | G7076 | G3717 | G282980 | G104909134 | G1394 | G3762 | G152273 | G378938 | G1727 | G196 | G776 | G4923 | G55757 | G9475 | G1080 | G154 | G5138 | G2982 | G57510 | G5947 | G6649 | G57537 | G146 | Dopamine receptor (nonspecified subtype) | L-Type calcium channel (nonspecified subtype) | P6058 | G50508 | G5153 | G5216 | G6927 | G5901 | P18298 | G160418 | G5140 | G3362 | G7428 | G1559 | G2043 | G2548 | G2778 | HTR1B | G1573 | G1906 | G760 | G29904 | G7296 | G100288077 | G105371702 | G22854 | G23194 | G2358 | G2944 | G5289 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | G7124 | G4638 | Organic anion transporters (OATs) (nonspecified subtype) | alpha1-Adrenoceptor (nonspecified subtype) | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | P2X Receptor (nonspecified subtype) | G644890 | G2219 | G5444 | G54920 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | P13024 | P15736 | Histone deacetylase (nonspecified subtype) | G406938 | G3291 | P16740 | G623 | G3908 | G4047 | G2027 | G133 | G56683 | G467 | G79400 | G348 | Vasopressin Receptor (nonspecified subtype) | G6523 | Cyclooxygenase (COX) (nonspecified subtype) | G773 | G27346 | G54822 | Gastric H+/K+-ATPase | G768 | G5781 | G3358 | G4508 | G3576 | G51185 | G114548 | G8170 | G8877 | G7054 | G2028 | G2869 | G5300 | G84909 | G54212 | G128 | G3763 | Cannabinoid receptor (nonspecified subtype) | G406996 | G718 | G100616147 | Adenosine receptor (nonspecified subtype) | G1588 | G170691 | G6853 | G4160 | G7369 | G32 | P24924 | G3899 | G680 | G1814 | G27035 | G177 | G2199 | G23345 | G5328 | G5602 | G165186 | G186 | G104384744 | G4624 | G9149 | G2984 | G3075 | Nitric oxide synthase (NOS) (nonspecified subtype) | G41 | G22953 | G240 | G55139 | G57016 | G131578 | G3818 | G26279 | G8645 | G27302 | G3146 | G6347 | Urea transporter (nonspecified subtype) | G7148 | G79068 | G5422 | G9340 | Carbonic Anhydrase V (nonspecified subtype) | G101929710 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | G5027 | G23408 | G1889 | G5045 | G9365 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | G8529 | G5648 | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | G596 | G6531 | G7768 | G100505549 | Calcium-activated chloride channel regulators (nonspecified subtype) | Potassium Channels (nonspecified subtype) | G4881 | G23632 | G2740 | G5754 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | G7157 | G64839 | G2831 | G9290 | G170692 | G7040 | G2149 | G10699 | Arginase (nonspecified subtype) | Endothiapepsin (nonspecified subtype) | G3764 | G2317 | G54932 | Myosin (nonspecified subtype) | Angiotensin receptor (AT) (nonspecified subtype) | G3991 | G7099 | G5294 | G284 | G3779 | G4142 | G5021 | G10019 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | G4129 | G4745 | G25 | G6427 | G81926 | Endothelin receptor (nonspecified subtype) | G3736 | G221935 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | G1585 | G406973 | NADPH Oxidase (nonspecified subtype) | G127435 | G735 | G47 | G3162 | Aurora Kinase (nonspecified subtype) | P10999 | Tryptophan 5-Monooxygenase (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | G1901 | G338442 | G1401 | G147 | G26011 | G6331 | G8435 | G8862 | G983 | G114781 | G5896 | G6774 | G54800 | Neurotensin receptor (nonspecified subtype) | G3606 | G143872 | G4048 | G6934 | G7048 | G105370003 | G149233 | alpha-Amylase (nonspecified subtype) | G4509 | G799 | G27347 | G56729 | P34550 | G4540 | G79798 | G3283 | G1129 | G259230 | G1141 | G1407 | G4864 | G23564 | G290 | G64421 | G3766 | G1579 | G2034 | G148641 | G1524 | G1594 | G2030 | G5972 | G7350 | G5266 | G31 | G5788 | G59340 | G2863 | G580 | G5997 | G6585 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | G102723321 | G23410 | G5592 | G7804 | G107985578 | G5724 | G10891 | P5859 | G4353 | G5136 | G144453 | G156 | G5547 | G134864 | G50943 | G257169 | G3481 | G1395 | G6647 | G4988 | P36339 | G761 | G10013 | G3091 | Superoxide dismutase (SOD) (nonspecified subtype) | G1215 | P16192 | G64072 | G4882 | G115 | G5230 | G8863 | G9033 | G3352 | G387 | G221955 | G574501 | G6311 | G1909 | G11318 | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | Phosphodiesterase (nonspecified subtype) | G152 | G1636 | G8974 | G6097 | Vasopressin V1 Receptor (nonspecified subtype) | Imidazoline receptor (nonspecified subtype) | G1576 | G1630 | G4179 | G9388 | G5139 | G246 | G5586 | G627 | G102723487 | G3363 | G147968 | G5168 | G54805 | G55244 | G105370115 | G3620 | G6546 | G2169 | Bradykinin receptor (nonspecified subtype) | G4057 | G4986 | G5538 | G3066 | G6517 | G2642 | G91662 | G11255 | G3593 | G6401 | G3708 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G6916 | G9533 | G1535 | P6747 | G1991 | G80036 | G9982 | G254827 | G9252 | G9718 | G1113 | G10451 | G1269 | G6326 | G7222 | G4780 | G23144 | G552 | G9863 | Monoamine oxidase (MAO) (nonspecified subtype) | G7494 | G6557 | G717 | G3949 | G10607 | G1674 | G5320 | G1012 | G1509 | G6524 | G151306 | Epoxide Hydrolase (nonspecified subtype) | P32831 | G1380 | G3767 | Interleukin 17 (nonspecified subtype) | G407002 | G207 | G283450 | G1948 | G762 | G120892 | G64428 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | Carbonic Anhydrase (nonspecified subtype) | G624 | G3751 | G8912 | G1813 | G4982 | G5122 | G5142 | G55328 | G5820 | G3757 | G154215 | G7881 | G2859 | G112399 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | G4306 | G1071 | G10841 | G338557 | CCK receptor (nonspecified subtype) | G1557 | G6720 | G1644 | G100996758 | G3077 | G154664 | G4571 | G774 | G2475 | G829 | G5159 | G100533464 | G54897 | G89858 | G11132 | G1281 | G629 | G4868 | G5465 | Heat shock protein 90 (nonspecified subtype) | G731 | G5550 | G1021 | G92291 | Phosphodiesterase 6 (PDE6) (nonspecified subtype) | G55553 | Prostanoid Receptor (nonspecified subtype) | G1445 | G4627 | G4753 | G4883 | G8078 | G105370438 | G105377304 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | G6580 | G221692 | G2693 | G132 | Calcium channel (nonspecified subtype) | G6558 | G79054 | Protein kinase C (nonspecified subtype) | G4023 | G7450 | G84867
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Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Mesothelioma, Malignant | Metabolic Diseases | Metabolic Syndrome | Metachondromatosis | Metachromatic Leukodystrophy | Metanephric Adenoma | Metaphyseal Chondrodysplasia, Schmid Type | Metatropic Dysplasia | Methemoglobinemia | Methemoglobinemia Type IV | Methylmalonic Acidemia | Methylmalonic Aciduria And Homocystinuria, CblC Type | Mevalonate Kinase Deficiency | Micro Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Microcephalic Primordial Dwarfism | Microcephaly | Microcephaly, Seizures, And Developmental Delay | Micropenis | Microphthalmia | Microphthalmia, Syndromic 7 | Microtia | Microvillus Inclusion Disease | Migraine | Milk Allergy | MIRAGE Syndrome | Mitochondrial Cytopathy | Mitochondrial Disease | Mitochondrial DNA Depletion Syndrome | Mitochondrial DNA Depletion Syndrome 13 | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Mitochondrial Encephalomyopathy | Mitochondrial Myopathy | Mixed Connective Tissue Disease | Miyoshi Myopathy | Mohr-Tranebjaerg Syndrome | Molybdenum Cofactor Deficiency | Monilethrix | Mood Disorder | Mosaic Variegated Aneuploidy Syndrome 2 | Motion Sickness | Motor Neuron Diseases | Mountain Sickness | Moyamoya Disease | Muckle-Wells Syndrome | Mucolipidosis | Mucolipidosis Type II | Mucolipidosis Type III | Mucolipidosis Type IV | Mucormycosis | Muir-Torre Syndrome | Multicentric Carpotarsal Osteolysis Syndrome | Multicystic Renal Dysplasia | Multifocal Motor Neuropathy | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Multiple Epiphyseal Dysplasia | Multiple Hamartoma Syndrome | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Multiple Myeloma | Multiple Sclerosis | Multiple Sclerosis, Chronic Progressive | Multiple Sclerosis, Primary Progressive | Multiple Sclerosis, Relapsing-remitting | Multiple Sclerosis, Secondary Progressive | Multiple Sulfatase Deficiency | Multiple System Atrophy | Multisystemic Smooth Muscle Dysfunction Syndrome | Mumps | Muscle Wasting | Muscular Dystrophy | Myasthenia | Myasthenia Gravis | Mycosis Fungoides | Myelitis | Myelitis, Transverse | Myelodysplasia | Myelofibrosis | Myeloid Leukemia | Myelomeningocele | Myhre Syndrome | Myocardial Infarction | Myocarditis | Myoclonic Atonic Epilepsy | Myoclonic Epilepsy With Ragged Red Fibers | Myoclonus | Myoclonus-dystonia Syndrome | Myofibrillar Myopathy | Myofibromatosis | Myopathy | Myopia | Myosin Storage Myopathy | Myositis | Myositis, Focal | Myotonia | Myotonic Disorders | N-acetylglutamate Synthase Deficiency | Nager Acrofacial Dysostosis | Nail Disorder, Nonsyndromic Congenital | Nail-Patella Syndrome | Nance-Horan Syndrome | Nanophthalmos | Narcolepsy | Nasodigitoacoustic Syndrome | NDH Syndrome | Necrobiosis Lipoidica | Necrotizing Autoimmune Myopathy | Nemaline Myopathy | Nemaline Myopathy 10 | Nemaline Myopathy 8 | Neonatal Progeroid Syndrome | Neovascular Glaucoma | Nephritis, Interstitial | Nephroblastoma | Nephrocalcinosis | Nephronophthisis | Nephropathy | Nephrosclerosis | Nephrotic Syndrome | Nephrotic Syndrome Type 1
