Depression
About the Disease
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological
Common Targets
G1454 | G3757 | G54661 | G8658 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | G1644 | G5332 | G8912 | G64708 | G51311 | G10013 | G1053 | G105370496 | G11255 | G3359 | G6622 | G1017 | G3066 | G5978 | G124274 | G7223 | G6097 | G3620 | G22878 | P12956 | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G54664 | G3355 | Prostaglandin EP Receptor (nonspecified subtype) | G2067 | G774 | P32835 | G63895 | G5015 | G105377329 | G595 | G6507 | G627 | G100861519 | G552 | G9536 | G5771 | P6058 | G4157 | G91120 | G6870 | G8379 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | G120892 | G781 | G80298 | G10531 | G22979 | G9170 | G9254 | G6580 | cAMP Phosphodiesterase (nonspecified subtype) | P32836 | G1473 | G3746 | G7040 | G5550 | G1021 | Tyrosine-Protein Kinases Src (nonspecified subtype) | G165829 | G6865 | G4804 | G2021 | G2557 | G6752 | G207 | G5789 | Kainate Receptor (GluR) (nonspecified subtype) | G3738 | G3782 | G3814 | G3235 | G6571 | G2872 | G2915 | G4306 | G9686 | P32844 | G1408 | G2629 | P18508 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | Voltage-gated K(v) channel (nonspecified subtype) | G763 | G2644 | G2693 | G10743 | G1557 | G7008 | G51555 | G9132 | G2905 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G1610 | G23040 | G5142 | G101927825 | G5590 | G3026 | G4842 | G51286 | G1019 | G4986 | G51368 | G2902 | G57563 | G1132 | Tachykinin Receptor (nonspecified subtype) | P32845 | G4543 | G7068 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | Interleukin-1 (nonspecified subtype) | G5914 | G4988 | G112464 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | G2280 | G8140 | G9293 | G2972 | G9722 | G338567 | G115207 | G148 | G6715 | G1815 | G51289 | G9392 | G8242 | G5321 | G1636 | P10238 | G409 | G2784 | G10457 | G387129 | Thyroid hormone receptor (nonspecified subtype) | G267012 | G5578 | G6093 | G151 | G4886 | G1269 | G4049 | G51083 | G27136 | G11343 | G6328 | G5923 | G2053 | G3084 | G57795 | G1432 | G100302640 | P11019 | G2890 | G4780 | G10280 | G3786 | Somatostatin receptor (nonspecified subtype) | G5465 | G553 | G5604 | Calcium channel (nonspecified subtype) | G65251 | G4595 | Alpha-2 Adrenergic receptors (nonspecified subtype) | G765 | G105377703 | G7224 | G3120 | G3274 | G2561 | G2566 | G10226 | G6446 | G2100 | G10171 | G2916 | Lipoxygenase (nonspecified subtype) | G4128 | G1020 | G1128 | G7299 | G5137 | G57528 | G1496 | G1813 | G187 | G27250 | G3747 | G50628 | G2688 | G8913 | G5924 | G142 | G389421 | G55902 | G6581 | G255239 | Small Conductance Calcium-Activated Potassium Channel (SK) (nonspecified subtype) | G1312 | G79054 | G23476 | G24139 | G5241 | G5293 | G9817 | G22986 | G2898 | G105373710 | G56413 | G79774 | G887 | G3360 | G282706 | G10846 | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | Estrogen receptor (nonspecified subtype) | G4158 | G101730217 | G2906 | G8600 | G8841 | G3061 | G109729137 | G3156 | G3776 | G6753 | G4968 | G150383 | G683 | G5024 | G79814 | G3350 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | G136 | G408 | G6530 | G4773 | G2912 | G134 | G8484 | G5533 | G3065 | G1385 | Alcohol Dehydrogenase (nonspecified subtype) | G23411 | G5152 | G3399 | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel (nonspecified subtype) | G1816 | G23671 | G4205 | G4552 | G3357 | Neurotrophic Factor (nonspecified subtype) | G1268 | G3952 | G3588 | alpha-Adrenoceptor (nonspecified subtype) | G56658 | alpha-Secretase (nonspecified subtype) | P19243 | Chloride channel (nonspecified subtype) | G2272 | G59283 | G6609 | G8324 | G6536 | G29063 | Opioid receptor (nonspecified subtype) | G151449 | G51393 | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | G775 | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | G4887 | G8856 | G105369441 | G1859 | G4916 | G1393 | Adenylate Cyclase (nonspecified subtype) | G5468 | G9407 | G6511 | P6320 | G54207 | G5595 | G2917 | G3290 | P24881 | G1139 | P16176 | G155 | G4137 | G2892 | G55313 | G5742 | G3361 | Melatonin receptor (nonspecified subtype) | G766 | G27154 | G2739 | G554 | G64400 | G7442 | G25902 | G54487 | G5467 | Histone acetyltransferase (HAT) (nonspecified subtype) | G590 | G2567 | G4544 | G84894 | G135 | G150 | G1803 | G2837 | G6329 | G196743 | G5287 | P11113 | G2099 | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | G145173 | G105375983 | G581 | G65268 | Arrestin (nonspecified subtype) | G8444 | G57210 | G5020 | G112812 | G5770 | Sphingomyelin phosphodiesterase (nonspecified subtype) | G121275 | G3480 | Pim Kinase (nonspecified subtype) | P5867 | G6582 | G5079 | G4050 | G10723 | G107984098 | G125 | P6884 | KCNQ Channels (K(v) 7) (nonspecified subtype) | G43 | G4987 | G282973 | G1066 | G4159 | G5054 | G2932 | G4316 | G4852 | G2289 | G6095 | P40594 | G2147 | G7498 | G150677 | G2903 | G1435 | G146722 | Orexin receptor (nonspecified subtype) | G150678 | G5551 | G6612 | G6538 | G706 | G5617 | G5837 | G6754 | G8312 | G5580 | G6358 | G4889 | G836 | G2562 | G5327 | G3741 | G610 | G8398 | G100130889 | G2899 | G2918 | G3601 | G140 | G7225 | G4985 | G27445 | G3630 | G2533 | G5214 | G84867 | Mitogen-Activated Protein Kinase (nonspecified subtype) | G4311 | G6502 | G4318 | G2554 | G2908 | sigma Receptor (nonspecified subtype) | G153 | G3990 | G7022 | G7124 | G114 | G3777 | G6539 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | G2255 | G497258 | G3062 | G375449 | G1812 | G1016 | G121278 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | G2538 | G10235 | Trypsin (nonspecified subtype) | G23028 | G9568 | G1131 | G54820 | G9378 | G54919 | G4233 | G460 | G84062 | G101928331 | Sodium channel (nonspecified subtype) | G5143 | beta-Adrenoceptor (nonspecified subtype) | G5536 | G2166 | G10203 | G105369749 | G1577 | G6750 | G5147 | G5153 | G3953 | G1103 | G6256 | G367 | G104909134 | G56479 | G5743 | Caspase (nonspecified subtype) | G10255 | G57104 | G6833 | G11076 | G146 | G23235 | G5138 | G50674 | G101928354 | P11025 | G130013 | P32313 | P6321 | G272 | G2913 | G3552 | Dopamine receptor (nonspecified subtype) | G5243 | G6281 | P33717 | G3784 | G5455 | G6323 | G6999 | G7166 | G7421 | G1394 | G4313 | G7296 | G5605 | G9737 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | G4000 | G196 | G51305 | G1027 | L-Type calcium channel (nonspecified subtype) | G3362 | G1606 | G27346 | Vasopressin Receptor (nonspecified subtype) | G6532 | G55972 | G29 | G2911 | G2358 | G5080 | G2558 | G9584 | G79602 | G79661 | G8654 | G6529 | G4835 | G10752 | G9992 | P32669 | G3586 | Adenosine receptor (nonspecified subtype) | G1786 | G6540 | Cannabinoid receptor (nonspecified subtype) | G4524 | G2563 | G9149 | G7054 | G5602 | G9475 | HTR1B | G6335 | G79966 | G23241 | G80022 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | G3791 | G6652 | G886 | G6523 | G5328 | G8755 | G7064 | G10888 | G5992 | G3790 | G4907 | G3269 | Focal Adhesion Kinases (FAK) (nonspecified subtype) | G41 | G1956 | G7444 | G154 | P6348 | G7077 | G5141 | G3458 | G1555 | Gastric H+/K+-ATPase | G747 | G2778 | G2548 | G10135 | G9340 | G56288 | G123041 | Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) | G6869 | G5588 | G9509 | G3356 | G4843 | G6310 | Histamine Receptor (HR) (nonspecified subtype) | G4745 | G3991 | G7428 | G84251 | G105378797 | G64067 | alpha1-Adrenoceptor (nonspecified subtype) | G54583 | G8989 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | G2555 | Histone deacetylase (nonspecified subtype) | G6755 | G177 | G2571 | G84765 | G4160 | G84448 | G3146 | P16191 | G7422 | G105376627 | G105378800 | Neurotensin receptor (nonspecified subtype) | Arginase (nonspecified subtype) | G92737 | G9572 | G100996447 | G340061 | P38079 | G100113403 | G4282 | G5027 | G2692 | Nitric oxide synthase (NOS) (nonspecified subtype) | G2950 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | G7266 | G7471 | G60495 | P34550 | G6751 | G79068 | G51490 | G338442 | G1588 | G4323 | G348980 | G3570 | G2914 | G3654 | P9058 | G5494 | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | G147 | G200909 | G238 | G56130 | G107985688 | G3358 | G339403 | G1407 | G1453 | G3780 | G1814 | G3766 | G8445 | G57486 | G4548 | G79981 | G8436 | G2863 | G9150 | G3565 | P32822 | Inward Rectifier Potassium Channel (nonspecified subtype) | G240 | G983 | G5136 | G547 | G348 | P16740 | G1401 | G51059 | G2559 | G290 | G56963 | P16192 | P17840 | G51185 | G8811 | Glutamate Receptor Ionotropic (nonspecified subtype) | G5581 | G156 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | G5972 | G382 | Potassium Channels (nonspecified subtype) | G221955 | G1141 | G1395 | G64843 | G4129 | G5021 | G6531 | G2587 | G2740 | G2847 | G134864 | Inward Rectifier Potassium Channel (nonspecified subtype) | G56923 | G3306 | G6506 | G83999 | G100505894 | P32823 | G1501 | G2840 | G1129 | G9290 | G9479 | Melanocortin receptor (nonspecified subtype) | G5732 | G3553 | G4953 | G3352 | G6840 | G9388 | G5999 | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | G9252 | G9575 | G3569 | G3576 | G1843 | G4803 | G83746 | Galanin receptor (nonspecified subtype) | G7222 | G2904 | G114548 | Vasopressin V1 Receptor (nonspecified subtype) | G3745 | G4161 | G5150 | G105379109 | G154141 | G10413 | Acyl-CoA Synthetase Short-Chain (nonspecified subtype) | G3785 | cAMP Responsive Element Binding Protein (CREB) (nonspecified subtype) | G4935 | G84634 | G100616414 | G80036 | G2556 | G8934 | G102723838 | G4915 | Monoamine oxidase (MAO) (nonspecified subtype) | G64077 | G152 | G100302174 | G2900 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | G9229 | G105379232 | G222962 | G2931 | G115004 | Phosphodiesterase (nonspecified subtype) | G126014 | G5144 | G8564 | G9463 | G140733 | G5122 | G10343 | G8864 | P32833 | CCK receptor (nonspecified subtype) | G2668 | G3363 | G6326 | G9369 | P6747 | G22933
The "Target / Biomarker Review Report" is a comprehensive and customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about the Target(s) / Biomarker(s) of your choice related to Depression, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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