Heme Oxygenase (HO) (nonspecified subtype) Related Diseases

Heme Oxygenase (HO) (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Crigler-Najjar Syndrome
Crigler-Najjar Syndrome, Type I, also known as crigler-najjar syndrome, is related to crigler-najjar syndrome, type ii and cardiomyopathy, dilated, with hypergonadotropic hypogonadism. An important gene associated with Crigler-Najjar Syndrome, Type I is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. The drugs Diazepam and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include Liver, brain and skin, and related phenotypes are jaundice and prolonged neonatal jaundice

3) Stroke, Ischemic
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

4) Stroke, Hemorrhagic
Hemorrhage, Intracerebral, also known as intracerebral hemorrhage, is related to cerebral amyloid angiopathy, app-related and porencephaly, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Hemorrhage, Intracerebral is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Signaling by Receptor Tyrosine Kinases and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Progesterone and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are growth/size/body region and nervous system

5) Stroke
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

6) IgA Nephropathy
Iga Glomerulonephritis, also known as iga nephropathy, is related to tonsillitis and glomerulonephritis. An important gene associated with Iga Glomerulonephritis is IGAN1 (IgA Nephropathy), and among its related pathways/superpathways are CCL18 signaling pathway and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart, and related phenotypes are renal/urinary system and homeostasis/metabolism

7) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

8) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

9) Multiple Myeloma
Myeloma, Multiple, also known as multiple myeloma, is related to monoclonal gammopathy of uncertain significance and plasma cell neoplasm. An important gene associated with Myeloma, Multiple is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Busulfan and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are osteopenia and pathologic fracture

10) Polycystic Kidney, Autosomal Dominant
Autosomal Dominant Polycystic Kidney Disease, also known as polycystic kidney disease, adult type, is related to polycystic kidney disease and polycystic kidney disease 1 with or without polycystic liver disease. An important gene associated with Autosomal Dominant Polycystic Kidney Disease is PKD1 (Polycystin 1, Transient Receptor Potential Channel Interacting), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and mTOR Signaling. The drugs Candesartan cilexetil and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and pancreas, and related phenotypes are renal cyst and decreased glomerular filtration rate

11) Focal Segmental Glomerulosclerosis
Focal Segmental Glomerulosclerosis, also known as familial idiopathic steroid-resistant nephrotic syndrome, is related to focal segmental glomerulosclerosis 2 and focal segmental glomerulosclerosis 5. An important gene associated with Focal Segmental Glomerulosclerosis is NPHS1 (NPHS1 Adhesion Molecule, Nephrin), and among its related pathways/superpathways are Cell junction organization and Nephrotic syndrome. The drugs Dapagliflozin and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include Kidney, bone marrow and bone, and related phenotypes are no effect and no effect

12) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

13) Acute Kidney Injury
Acute Kidney Failure, also known as acute renal failure, is related to hemolytic-uremic syndrome and hemolytic uremic syndrome, atypical 1. An important gene associated with Acute Kidney Failure is MGAT3-AS1 (MGAT3 Antisense RNA 1), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and "Uricosurics Pathway, Pharmacodynamics". The drugs Desflurane and Racephedrine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are homeostasis/metabolism and cardiovascular system

14) Chronic Myeloid Leukemia
Leukemia, Chronic Myeloid, also known as chronic myelogenous leukemia, is related to atypical chronic myeloid leukemia, bcr-abl1 negative and juvenile myelomonocytic leukemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Chronic Myeloid is ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Overview of interferons-mediated signaling pathway and VEGF Pathway (Tocris). The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related phenotypes are myeloproliferative disorder and splenomegaly

15) Chronic Kidney Disease
Chronic Kidney Disease, also known as chronic renal disease, is related to kidney disease and end stage renal disease, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with Chronic Kidney Disease is COL4A4 (Collagen Type IV Alpha 4 Chain), and among its related pathways/superpathways are Signal Transduction and Primary focal segmental glomerulosclerosis (FSGS). The drugs Chlorhexidine and Fosinopril have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are homeostasis/metabolism and renal/urinary system

16) Lymphoma
Lymphosarcoma, also known as lymphoma, diffuse, is related to lymphoma, non-hodgkin, familial and lymphoma, hodgkin, classic. An important gene associated with Lymphosarcoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are Direct p53 effectors and Interleukin-4 and Interleukin-13 signaling. The drugs Crofelemer and Aprepitant have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and myeloid.

17) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

18) Idiopathic Pulmonary Fibrosis
Acute Interstitial Pneumonia, also known as acute interstitial pneumonitis, is related to mikulicz disease and pulmonary fibrosis, and has symptoms including dyspnea on exertion and dry cough. An important gene associated with Acute Interstitial Pneumonia is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Disease and Innate Immune System. The drugs Nintedanib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and bone, and related phenotypes are dyspnea and respiratory failure

19) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

20) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

21) Leukemia
Leukemia, also known as leukaemia, unspecified, without mention of remission, is related to myeloid leukemia and leukemia, chronic myeloid, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia is MIR27A (MicroRNA 27a), and among its related pathways/superpathways are NF-kappaB Signaling and Imatinib and chronic myeloid leukemia. The drugs Azacitidine and Decitabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and t cells, and related phenotypes are Increased HDAC inhibitor resistance and endocrine/exocrine gland

22) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

23) Myeloid Leukemia
Myeloid Leukemia, also known as myeloid leukaemia, is related to leukemia, acute myeloid and leukemia, chronic myeloid. An important gene associated with Myeloid Leukemia is MIR99AHG (Mir-99a-Let-7c Cluster Host Gene), and among its related pathways/superpathways are HIF-1-alpha transcription factor network and Wnt/beta-catenin signaling pathway in leukemia. The drugs Nicotine and Mitoxantrone have been mentioned in the context of this disorder. Affiliated tissues include myeloid tissue, myeloid and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

24) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

25) Diabetic Neuropathy
Diabetic Neuropathy, also known as diabetic neuropathies, is related to microvascular complications of diabetes 3 and diabetic polyneuropathy, and has symptoms including neuralgia and sciatica. An important gene associated with Diabetic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and CREB Pathway. The drugs Histamine and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and dorsal root ganglion, and related phenotypes are no effect and no effect

26) Diabetic Nephropathy
Microvascular Complications of Diabetes 2, also known as microvascular complications of diabetes, susceptibility to, 2, is related to microvascular complications of diabetes 3 and background diabetic retinopathy. An important gene associated with Microvascular Complications of Diabetes 2 is EPO (Erythropoietin). The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and retina.

27) Fibrosis
Fibrosis of Extraocular Muscles, Congenital, 1, also known as fibrosis of extraocular muscles, congenital, 3b, is related to moebius syndrome and fibrosis of extraocular muscles, congenital, 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Fibrosis of Extraocular Muscles, Congenital, 1 is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Vesicle-mediated transport. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone marrow, and related phenotypes are esotropia and exotropia

28) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

29) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

30) Nephrotic Syndrome
Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome, also known as barakat syndrome, is related to membranoproliferative glomerulonephritis and glomerulonephritis. An important gene associated with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome is GATA3 (GATA Binding Protein 3), and among its related pathways/superpathways are Cell junction organization and Primary focal segmental glomerulosclerosis (FSGS). The drugs Entecavir and Furosemide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and uterus, and related phenotypes are hypoparathyroidism and renal dysplasia

31) Gastritis
Gastritis, also known as acute gastric mucosal erosion, is related to gastritis, familial giant hypertrophic and granulomatous gastritis, and has symptoms including dyspepsia and gastric irritation. An important gene associated with Gastritis is GAST (Gastrin), and among its related pathways/superpathways are Innate Immune System and IL-1 Family Signaling Pathways. The drugs Esomeprazole and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include spleen, t cells and liver.

32) Gastrointestinal Disorders
Gastrointestinal System Disease, also known as gastrointestinal disease, is related to crohn's disease and stomach disease, and has symptoms including peeling tongue, catarrh and blood in stool. An important gene associated with Gastrointestinal System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. The drugs Indomethacin and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include gastrointestinal tract, small intestine and liver.

33) Autoimmune Disease
Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and systemic lupus erythematosus. An important gene associated with Autoimmune Disease is AIS4 (Autoimmune Disease, Susceptibility To, 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and skin, and related phenotypes are autoimmune antibody positivity and endocrine/exocrine gland

34) Uveitis
Uveitis is related to anterior uveitis and pars planitis. An important gene associated with Uveitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Lidocaine and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

35) Anemia
Deficiency Anemia, also known as anemia, is related to iron deficiency anemia and diamond-blackfan anemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Deficiency Anemia is HBA2 (Hemoglobin Subunit Alpha 2), and among its related pathways/superpathways are Cellular responses to stimuli and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Iron protein succinylate and Proguanil have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, kidney and heart, and related phenotypes are homeostasis/metabolism and liver/biliary system

36) Sickle Cell Disease
Sickle Cell Anemia, also known as hemoglobin sc disease, is related to hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and deficiency anemia, and has symptoms including abdominal pain, angina pectoris and chest pain. An important gene associated with Sickle Cell Anemia is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Golgi-to-ER retrograde transport and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Deferoxamine and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include Blood, bone marrow and bone, and related phenotypes are chronic hemolytic anemia and recurrent infections

37) Hyperbilirubinemia
Bilirubin Metabolic Disorder, also known as hyperbilirubinemia, is related to gilbert syndrome and crigler-najjar syndrome, type i, and has symptoms including icterus, polydipsia and muscle weakness. An important gene associated with Bilirubin Metabolic Disorder is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. The drugs Oxytocin and Ritonavir have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and breast.

38) Hyperbilirubinemia, Neonatal
Neonatal Jaundice, also known as hyperbilirubinemia, neonatal, is related to pyruvate kinase deficiency of red cells and crigler-najjar syndrome, type i, and has symptoms including icterus and newborn physiological jaundice. An important gene associated with Neonatal Jaundice is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. The drugs Oxytocin and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and brain, and related phenotypes are no effect and no effect

39) Melanoma
Melanoma, also known as malignant melanoma, is related to skin melanoma and melanoma, cutaneous malignant 1, and has symptoms including exanthema and pruritus. An important gene associated with Melanoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Vindesine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are normal and pigmentation

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