Leukemia
About the Disease
Leukemia, also known as leukaemia, unspecified, without mention of remission, is related to myeloid leukemia and leukemia, chronic myeloid, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia is MIR27A (MicroRNA 27a), and among its related pathways/superpathways are NF-kappaB Signaling and Imatinib and chronic myeloid leukemia. The drugs Azacitidine and Decitabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and t cells, and related phenotypes are Increased HDAC inhibitor resistance and endocrine/exocrine gland
Common Targets
G5294 | G3791 | G3132 | G7515 | G7525 | G3812 | G6714 | G22933 | G29117 | G3055 | G5820 | DNA Methyltransferase (DNMT) (nonspecified subtype) | G1053 | G1535 | G6790 | G7006 | G22978 | G472 | G51074 | P16165 | G3757 | G25 | G1956 | G2268 | Cyclin B (nonspecified subtype) | G3717 | G4683 | G3576 | Sphingosine kinase (nonspecified subtype) | G3845 | G11091 | G840 | G860 | CDK4/Cyclin D1 | P5575 | G6622 | G5693 | G3553 | G1806 | P5760 | G10892 | P12956 | G3133 | P5683 | G440 | G55170 | G5778 | G3593 | G8854 | Protein arginine N-methyltransferase (nonspecified subtype) | G3569 | G6774 | G1017 | P6176 | G7015 | G923 | G171023 | G763 | G1445 | G7037 | G1026 | Tyrosine-Protein Kinases Src (nonspecified subtype) | Serine/Threonine Kinase (nonspecified subtype) | G2872 | G695 | G10013 | G56341 | G3066 | Tachykinin Receptor (nonspecified subtype) | Cyclophilins (nonspecified subtype) | G55869 | G6608 | G11006 | G902 | G3620 | G909 | Heat shock protein 90 (nonspecified subtype) | P5859 | G5914 | CDK5/p25 | G282617 | G10964 | G3205 | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | G2623 | G595 | G10481 | G5880 | G284415 | P16514 | MLL1/MLL Complex | Thioredoxin-disulfide reductase (TrxR) (nonspecified subtype) | G1/S-specific cyclin-E (nonspecified subtype) | G340348 | G4988 | G1111 | G4869 | G4893 | G1021 | G28755 | G6093 | G3559 | G8140 | G2811 | G5578 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | Folate Receptor (nonspecified subtype) | P6058 | G84649 | G9212 | G558 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | G759 | Hedgehog Protein (nonspecified subtype) | Ephrin Receptor (nonspecified subtype) | G204 | G1233 | G660 | G3932 | Protein kinase C (nonspecified subtype) | G598 | P8262 | G2120 | Casein kinase I (nonspecified subtype) | G7297 | G5133 | P11442 | G1436 | G102724428 | G6046 | G5465 | G221037 | G11151 | G3815 | G1950 | G200424 | G7922 | G842 | G1050 | Phospholipase C (nonspecified subtype) | G415116 | G217 | G2547 | G1019 | G1020 | G10320 | G10673 | P12327 | G29126 | Integrin Receptor (nonspecified subtype) | G3563 | G1723 | G3135 | G24144 | G1441 | G1633 | G7150 | G4780 | G914 | G3297 | CDK9/Cyclin T1 | G7852 | G8569 | G9020 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | G6868 | G8600 | G4921 | G5291 | G2100 | G613 | G5604 | G115350 | G1543 | G23476 | G55870 | G3123 | P5614 | G4689 | G5293 | G331 | DNA Topoisomerase II (nonspecified subtype) | Adenylate Cyclase (nonspecified subtype) | G2261 | G23411 | G8396 | G1025 | Adenosine deaminase (nonspecified subtype) | G3614 | G3965 | G84159 | G3093 | G673 | G100 | G8841 | G1490 | G1043 | G960 | G115352 | G590 | P5762 | G1859 | G952 | G958 | G3903 | G7514 | G933 | G3276 | G5836 | G5595 | G160364 | Histone acetyltransferase (HAT) (nonspecified subtype) | G6850 | G5159 | G142 | G3702 | G4690 | G22992 | G26040 | G3122 | G22914 | G5467 | G1088 | P5833 | G9448 | G3169 | G10232 | G3065 | G581 | G904 | G4170 | G11025 | Tyrosine Kinase (nonspecified subtype) | P16126 | G2214 | G2042 | G51428 | G4582 | G4609 | G80312 | G6279 | G5727 | STAT5 (nonspecified subtype) | G3615 | G5580 | G5468 | P5662 | G216 | G5551 | G5770 | G841 | G79368 | G3105 | G920 | G43 | G2932 | G706 | G9429 | Heme Oxygenase (HO) (nonspecified subtype) | G931 | G4221 | G2475 | G10434 | Interferon alpha/beta Receptor (nonspecified subtype) | G924 | G970 | P16640 | CDK1/Cyclin B | G7517 | G4311 | G4860 | G10461 | Retinoid acid receptor (nonspecified subtype) | G3663 | G23414 | G6795 | G80319 | G28619 | G3480 | P18298 | G2324 | G2051 | G896 | G10803 | G54620 | P15736 | G4035 | G2186 | G84678 | G945 | G9929 | G2346 | Glycylpeptide N-tetradecanoyltransferase (nonspecified subtype) | G8792 | Elastase (nonspecified subtype) | G9971 | G3832 | G5147 | G5289 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | G4297 | G9759 | G3418 | P5753 | G1523 | G2033 | G7862 | G3556 | MLL/SET1 Complex | G23028 | Mitogen-Activated Protein Kinase (nonspecified subtype) | G2099 | G2444 | G2321 | G836 | G5223 | ADP/ATP Translocase (nonspecified subtype) | P23180 | Caspase (nonspecified subtype) | G100505478 | G916 | G7157 | G7301 | CDK2/Cyclin A | G10219 | G3125 | G640 | G6688 | G4919 | G100528032 | G11313 | G115650 | G4318 | G898 | G599 | G608 | Heat shock protein 70 (nonspecified subtype) | G8842 | P23188 | G6999 | G23235 | G8500 | G4298 | G7345 | G84444 | G84749 | G780 | G2356 | G6606 | G219931 | G5292 | Poly [ADP-ribose] polymerase (nonspecified subtype) | G2081 | G3552 | G4193 | G3603 | G22925 | G3592 | G8019 | G7415 | G7441 | G7518 | G760 | G1024 | G3558 | G5422 | G93100 | G4602 | G51104 | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | G6427 | G3579 | P6884 | G8577 | G4067 | G2204 | CDK2/Cyclin E | G23093 | G10988 | Aurora Kinase (nonspecified subtype) | G201633 | G2548 | G55611 | G5605 | G11238 | G5588 | G56919 | G150094 | G6693 | G1786 | G811 | G6776 | G79728 | G861 | G54106 | G974 | Cyclin A (nonspecified subtype) | CDK7/Cyclin H | G6607 | G834 | G5743 | G1493 | G7421 | G10135 | G7490 | G943 | G4233 | G5290 | G7298 | G5305 | G961 | G3127 | G8836 | G7124 | G951 | G2064 | G80329 | alpha-Amylase (nonspecified subtype) | G213 | G2322 | G4363 | G2534 | G332 | G5781 | G340061 | G5156 | G3128 | G10196 | G290 | G5788 | G65980 | G4524 | G3129 | G1719 | G4048 | P13024 | G7428 | G2146 | G4255 | G220 | G8289 | G9344 | Histone deacetylase (nonspecified subtype) | G7153 | G7294 | G83416 | G5243 | G921 | G10891 | G4548 | G10495 | G240 | G983 | G3455 | G23387 | G84791 | G930 | Glutathione peroxidase (nonspecified subtype) | G7307 | G6041 | G28638 | G3130 | G5266 | G1022 | G1843 | G80150 | G3718 | G238 | G3596 | G11040 | G3716 | G23532 | G2950 | G596 | G28639 | G3162 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | G5347 | G11200 | G7045 | G8795 | CDK4/Cyclin D3 | G51185
The "Target / Biomarker Review Report" is a comprehensive and customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about the Target(s) / Biomarker(s) of your choice related to Leukemia, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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