Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype) Related Diseases

Muscarinic Acetylcholine Receptor (mAChR) (nonspecified subtype)

Related Diseases

1) Migraine
Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine without aura, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Migraine with or Without Aura 1 is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Type II diabetes mellitus and Cellular roles of Anthrax toxin. The drugs Mineral oil and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and cortex, and related phenotypes are photophobia and vomiting

2) Stroke, Ischemic
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

3) Cluster Headache
Cluster Headache, also known as headache, cluster, is related to headache and trigeminal neuralgia, and has symptoms including headache and recurrent paroxysmal headache. An important gene associated with Cluster Headache is HCRTR2 (Hypocretin Receptor 2), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Zolmitriptan and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and brain.

4) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

5) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

6) Sjogren Syndrome
Sjogren Syndrome, also known as sjogren's syndrome, is related to mononeuritis multiplex and aplasia of lacrimal and salivary glands, and has symptoms including dryness of eye, eye manifestations and back pain. An important gene associated with Sjogren Syndrome is IFNG-AS1 (IFNG Antisense RNA 1), and among its related pathways/superpathways are Apoptosis and Autophagy and NF-kappaB Signaling. The drugs Fluorometholone and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include eye, salivary gland and skin, and related phenotypes are keratoconjunctivitis sicca and xerostomia

7) Open-angle Glaucoma
Open-Angle Glaucoma, also known as glaucoma, open-angle, is related to glaucoma 1, open angle, a and exfoliation syndrome. An important gene associated with Open-Angle Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are Extracellular matrix organization and Burn wound healing. The drugs Tobramycin and Polymyxin B have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and endothelial, and related phenotypes are nervous system and homeostasis/metabolism

8) Angina Pectoris
Angina Pectoris, also known as prinzmetal's variant angina, is related to polycythemia vera and intermittent claudication, and has symptoms including other and unspecified angina pectoris An important gene associated with Angina Pectoris is EDN1 (Endothelin 1), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Candesartan cilexetil and Amiodarone have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and bone marrow, and related phenotypes are homeostasis/metabolism and muscle

9) Bronchitis, Chronic
Bronchitis, also known as chronic bronchitis, is related to allergic asthma and haemophilus influenzae, and has symptoms including cough, shortness of breath and low fever. An important gene associated with Bronchitis is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are Signal Transduction and Innate Immune System. The drugs Cefdinir and Streptokinase have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and t cells, and related phenotypes are no effect and no effect

10) Bronchitis
Bronchitis, also known as chronic bronchitis, is related to allergic asthma and haemophilus influenzae, and has symptoms including cough, shortness of breath and low fever. An important gene associated with Bronchitis is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are Signal Transduction and Innate Immune System. The drugs Cefdinir and Streptokinase have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and t cells, and related phenotypes are no effect and no effect

11) Motion Sickness
Motion Sickness, also known as airsickness, is related to space motion sickness and allergic disease, and has symptoms including nausea, medically unexplained symptoms and hypertriglyceridemic waist. An important gene associated with Motion Sickness is HTR3A (5-Hydroxytryptamine Receptor 3A), and among its related pathways/superpathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). The drugs Meclizine and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and eye, and related phenotypes are abnormality of the nervous system and nervous system

12) Depression
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

13) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

14) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

15) Spasticity
Spasticity is related to spastic paraplegia 41, autosomal dominant and spastic paraplegia 19, autosomal dominant. An important gene associated with Spasticity is SPAST (Spastin), and among its related pathways/superpathways is Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skeletal muscle, and related phenotypes are nervous system and growth/size/body region

16) Hemorrhoids
Hemorrhoid, also known as hemorrhoids, is related to mucormycosis and internal hemorrhoid, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Hemorrhoid is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Menthol and Borage oil have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and spinal cord, and related phenotypes are neoplasm and muscle

17) Epilepsy
Epilepsy, also known as epilepsy syndrome, is related to epilepsy, myoclonic juvenile and childhood absence epilepsy, and has symptoms including back pain, headache and pain. An important gene associated with Epilepsy is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. The drugs Ethosuximide and Vigabatrin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and thalamus, and related phenotypes are nervous system and growth/size/body region

18) Sleep Apnea
Sleep Apnea, also known as sleep apnea syndromes, is related to central sleep apnea and obesity-hypoventilation syndrome, and has symptoms including apnea, back pain and cheyne-stokes respiration. An important gene associated with Sleep Apnea is AHDC1 (AT-Hook DNA Binding Motif Containing 1), and among its related pathways/superpathways are Signal Transduction and p70S6K Signaling. The drugs Montelukast and Opium have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and tongue, and related phenotypes are homeostasis/metabolism and nervous system

19) Sleep Apnea, Obstructive
Apnea, Obstructive Sleep, also known as obstructive sleep apnea syndrome, is related to obesity-hypoventilation syndrome and hypercholesterolemia, familial, 1, and has symptoms including apnea, back pain and cheyne-stokes respiration. An important gene associated with Apnea, Obstructive Sleep is LEP (Leptin), and among its related pathways/superpathways are Metabolism of proteins and Signal Transduction. The drugs Opium and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include heart, tongue and endothelial, and related phenotypes are anosmia and obstructive sleep apnea

20) Neurogenic Bladder
Neurogenic Bladder, also known as neurogenic dysfunction of the urinary bladder, is related to urofacial syndrome 1 and lethal congenital contracture syndrome 2, and has symptoms including dysuria, meningism and pain. An important gene associated with Neurogenic Bladder is EBF3 (EBF Transcription Factor 3), and among its related pathways/superpathways are CREB Pathway and Purinergic signaling. The drugs Silodosin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and prostate, and related phenotypes are nervous system and homeostasis/metabolism

21) Schizophrenia
Schizophrenia, also known as schizophrenia with or without an affective disorder, is related to schizoaffective disorder and psychotic disorder, and has symptoms including sleep disturbances, photophobia and personality changes. An important gene associated with Schizophrenia is RTN4R (Reticulon 4 Receptor), and among its related pathways/superpathways are "Methylphenidate Pathway, Pharmacodynamics" and MTHFR deficiency. The drugs Molindone and Asenapine have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are eeg abnormality and hallucinations

22) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

23) Ischemia
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

24) Presbyopia
Presbyopia, also known as accommodation insufficiency of old age, is related to oculodentodigital dysplasia and retinal perforation, and has symptoms including aniseikonia An important gene associated with Presbyopia is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways is 1q21.1 copy number variation syndrome. The drugs Vitamins and Omega 3 Fatty Acid have been mentioned in the context of this disorder. Affiliated tissues include eye, breast and thymus, and related phenotypes are no effect and no effect

25) Irritable Bowel Syndrome
Irritable Bowel Syndrome, also known as irritable colon, is related to fibromyalgia and lactose intolerance, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Irritable Bowel Syndrome is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Clarithromycin and Simethicone have been mentioned in the context of this disorder. Affiliated tissues include colon, brain and kidney, and related phenotypes are homeostasis/metabolism and nervous system

26) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

27) Gastrointestinal Disorders
Gastrointestinal System Disease, also known as gastrointestinal disease, is related to crohn's disease and stomach disease, and has symptoms including peeling tongue, catarrh and blood in stool. An important gene associated with Gastrointestinal System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. The drugs Indomethacin and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include gastrointestinal tract, small intestine and liver.

28) Alopecia
Alopecia is related to alopecia universalis congenita and alopecia-mental retardation syndrome 1, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia is SASH1 (SAM And SH3 Domain Containing 1), and among its related pathways/superpathways are Direct p53 effectors and Validated transcriptional targets of TAp63 isoforms. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include Hair, and related phenotypes are no effect and no effect

29) Cystitis, Interstitial
Interstitial Cystitis, also known as painful bladder syndrome, is related to chronic pain and low compliance bladder, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Interstitial Cystitis is P3H4 (Prolyl 3-Hydroxylase Family Member 4 (Inactive)), and among its related pathways/superpathways are Signal Transduction and Overview of interferons-mediated signaling pathway. The drugs Hesperidin and Polidocanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and smooth muscle, and related phenotypes are abnormality of the menstrual cycle and abnormality of the urethra

30) Overactive Bladder
Low Compliance Bladder, also known as overactive bladder, is related to interstitial cystitis and paine syndrome, and has symptoms including dysuria, urgency of micturition and prostatism. An important gene associated with Low Compliance Bladder is P2RX3 (Purinergic Receptor P2X 3), and among its related pathways/superpathways are Signal Transduction and Myometrial relaxation and contraction pathways. The drugs Propiverine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, smooth muscle and prostate.

31) Thrombosis
Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to blood group, cromer system and protein-losing enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and endothelial, and related phenotypes are thrombocytosis and hepatomegaly

32) Myopia
Myopia, also known as near-sightedness, is related to night blindness, congenital stationary, type 1a and degenerative myopia, and has symptoms including aniseikonia An important gene associated with Myopia is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Extracellular matrix organization and Syndecan-1-mediated signaling events. The drugs Fluorometholone and Loteprednol etabonate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial.

33) Glaucoma
Intraocular Pressure Quantitative Trait Locus, also known as glaucoma, is related to primary angle-closure glaucoma and open-angle glaucoma. An important gene associated with Intraocular Pressure Quantitative Trait Locus is ZEB1 (Zinc Finger E-Box Binding Homeobox 1), and among its related pathways/superpathways are Clear cell renal cell carcinoma pathways and BMP signaling in eyelid development. The drugs Topiramate and Bromfenac have been mentioned in the context of this disorder. Affiliated tissues include Eye, retina and bone marrow, and related phenotypes are homeostasis/metabolism and nervous system

34) Hypertension
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure

35) Rhinitis
Chronic Rhinitis, also known as chronic rhinitis nos, is related to giant papillary conjunctivitis and allergic conjunctivitis, and has symptoms including purulent rhinitis, rhinorrhea and catarrh. An important gene associated with Chronic Rhinitis is HRH1 (Histamine Receptor H1), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Allograft rejection. The drugs Dexlansoprazole and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related phenotypes are immune system and respiratory system

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