SLC10A2: A Potential Drug Target and Biomarker for Ileal Na(+)/Bile Acid Cotransporter

Target Name: SLC10A2

NCBI ID: G6555

SLC10A2

SLC10A2: A Potential Drug Target and Biomarker for Ileal Na(+)/Bile Acid Cotransporter

Abstract:

Sodium-glucose cotransporter (SLC10A2) is a transmembrane protein that plays a crucial role in the regulation of bile acid transport in the intestine. The SLC10A2 gene has been identified as a potential drug target and biomarker for various diseases, including gastrointestinal diseases, such as inflammatory bowel disease and chronic constipation. This article will review the current literature on SLC10A2 and its potential as a drug target and biomarker, focusing on its function in bile acid transport and its potential clinical applications.

Introduction:

Sodium-glucose cotransporter (SLC10A2) is a transmembrane protein that is expressed in various tissues and cells in the body, including the small intestine, the liver, and the kidney. SLC10A2 is involved in the regulation of bile acid transport in the intestine, specifically in the movement of bile acids across the intestinal epithelium. Bile acids are essential for various physiological functions, including digestion and absorption of vitamins and minerals, but they can also cause various adverse effects, such as diarrhea, constipation, and liver damage. The SLC10A2 gene has been identified as a potential drug target and biomarker for various diseases, including gastrointestinal diseases, such as inflammatory bowel disease and chronic constipation.

Functional characterization of SLC10A2:

SLC10A2 is a member of the T-type transporter family, which includes proteins involved in the transport of various types of macromolecules across cell membranes. SLC10A2 is responsible for the transport of bile acids across the intestinal epithelium, Specifically, SLC10A2 is involved in the uptake and transport of both water-soluble and water-insoluble bile acids, such as cholic acid and bilirubin. The SLC10A2 protein has been shown to play a crucial role in the regulation of bile acid transport in the intestine, as Alterations in SLC10A2 expression or function have been observed in various gastrointestinal diseases.

Drug targeting of SLC10A2:

SLC10A2 has been identified as a potential drug target due to its involvement in the regulation of bile acid transport in the intestine. Several studies have shown that inhibitors of SLC10A2 can alter the expression and function of SLC10A2, leading to changes in bile acid transport (8 ). For example, one study reported that inhibitors of SLC10A2 reduced the expression and activity of SLC10A2 in the intestine, leading to increased bile acid excretion and improved constipation. Another study demonstrated that SLC10A2 inhibition improved the transport of water-soluble bile acids across the intestinal epithelium, but not water-insoluble bile acids.

Biomarker potential of SLC10A2:

SLC10A2 has also been identified as a potential biomarker for several gastrointestinal diseases, including inflammatory bowel disease and chronic constipation. Inflammatory bowel disease, also known as inflammatory colitis, is a chronic inflammatory condition of the intestine that can cause a variety of symptoms , including diarrhea, abdominal pain, and fatigue. Several studies have shown that changes in SLC10A2 expression and function contribute to the development and progression of inflammatory bowel disease. For example, one study reported that SLC10A2 was overexpressed in inflammatory bowel disease patients, and inhibition of SLC10A2 improved symptoms.

Chronic constipation is a common gastrointestinal disorder that can cause abdominal pain, bloating, and difficulty passing stool. Several studies have shown that SLC10A2 is involved in the regulation of bile acid transport in the intestine, and alterations in SLC10A2

Protein Name: Solute Carrier Family 10 Member 2

Functions: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321)

The "SLC10A2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC10A2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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