SLC12A4: Potential Drug Target and Biomarker for Cardiovascular Disorders

Target Name: SLC12A4

NCBI ID: G6560

SLC12A4

SLC12A4: Potential Drug Target and Biomarker for Cardiovascular Disorders

SLC12A4 (KCC1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the solute carrier family 12 (SLC12) and is responsible for transmitting essential nutrients, such as sodium and potassium, across cell membranes. SLC12A4 is also known as KCC1 because of its high affinity for positively charged ions, such as potassium.

SLC12A4 has been identified as a potential drug target due to its involvement in various physiological processes that are important for human health, such as brain function and cardiac function. Studies have shown that SLC12A4 is involved in the regulation of neuronal excitability, which is critical for the proper functioning of the brain and other nervous system cells.

Additionally, SLC12A4 has been shown to play a role in the regulation of cardiac function, which is essential for maintaining the health and wellbeing of the heart. Studies have shown that SLC12A4 is involved in the regulation of ion channels in heart cells, which are critical for the proper functioning of the heart's electrical activity.

SLC12A4 is also a potential biomarker for various diseases, including hypertension, heart failure, and neurodegenerative disorders. Studies have shown that SLC12A4 is often decreased in individuals with hypertension, heart failure, and other conditions that affect the cardiovascular system.

In conclusion, SLC12A4 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of various physiological processes that are essential for human health. As a potential drug target and biomarker, SLC12A4 is a promising target for the development of new treatments for a variety of cardiovascular and neurological disorders. Further research is needed to fully understand the role of SLC12A4 in various physiological processes and to develop effective treatments.

Protein Name: Solute Carrier Family 12 Member 4

Functions: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity)

The "SLC12A4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC12A4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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