SLC11A1: A Metal Ion Transporter in The Body (G6556)

Target Name: SLC11A1

NCBI ID: G6556

SLC11A1

SLC11A1: A Metal Ion Transporter in The Body

SLC11A1, also known as proton-coupled divalent metal ion transporter, member 1, is a protein that plays a crucial role in the regulation of metal ions in the body. It is a member of the solute carrier family 11, which is responsible for transporting a variety of different ions and molecules across cell membranes. SLC11A1 is expressed in many different tissues and cells in the body, including the brain, heart, and kidneys.

SLC11A1 is a transmembrane protein, which means that it spans the cell membrane and is located on both the intracellular and extracellular sides. It has a unique structure that allows it to transport a variety of different metal ions, including divalent ions such as calcium and magnesium . SLC11A1 has four transmembrane domains: an N-terminal cytoplasmic domain, a transmembrane domain, and two C-terminal intracellular domains.

The N-terminal cytoplasmic domain is the first part of the protein that is involved in the regulation of metal ions. It contains a protein-coding region that is responsible for the synthesis of the protein. The transmembrane domain is the second part of the protein and is responsible for the regulation of the transport of metal ions across the cell membrane. The C-terminal intracellular domains are the last part of the protein and are involved in the regulation of the intracellular distribution of the protein.

SLC11A1 is a metal ion transporter, which means that it is responsible for the transport of metal ions across the cell membrane. It has a specific affinity for divalent ions, which are ions that have a negative charge. SLC11A1 has a high affinity for calcium and magnesium divalent ions, which means that it is able to transport these ions across the cell membrane more efficiently than other proteins. This is important for the regulation of a variety of different physiological processes in the body, including muscle contractions, nerve impulses, and blood clotting.

SLC11A1 is also involved in the regulation of other ions and molecules that are important for cellular signaling and metabolism. For example, SLC11A1 has been shown to be involved in the regulation of the levels of insulin and growth factors in the body. It has also been shown to play a role in the regulation of ion channels in the brain, which are responsible for the flow of electrical signals in the nervous system.

SLC11A1 is a potential drug target for a variety of different diseases. For example, it is thought to be involved in the regulation of muscle contractions in the heart, which could make it a useful target for a drug that is used to treat heart failure. SLC11A1 is also thought to be involved in the regulation of the formation of blood clots, which could make it a useful target for a drug that is used to prevent blood clots.

In conclusion, SLC11A1 is a protein that plays a crucial role in the regulation of metal ions in the body. It is a member of the solute carrier family 11 and has a unique structure that allows it to transport a variety of different divalent ions across the cell membrane. SLC11A1 is also involved in the regulation of other ions and molecules that are important for cellular signaling and metabolism. As a result, it is a potential drug target for a variety of different diseases. Further research is needed to fully understand the role of SLC11A1 in the regulation of metal ions and other processes in the body.

Protein Name: Solute Carrier Family 11 Member 1

Functions: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes

The "SLC11A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC11A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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