MAN1B1: A Potential Drug Target for Inflammatory Diseases (G11253)

Target Name: MAN1B1

NCBI ID: G11253

MAN1B1

MAN1B1: A Potential Drug Target for Inflammatory Diseases

MAN1B1 (Mannosidase type 1B1) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the Mannoin-Saccharase family, which is a group of enzymes that are involved in the breakdown of complex carbohydrates.

One of the unique features of MAN1B1 is its ability to catalyze the breakdown of mannose, a type of carbohydrate that is found in many foods, such as honey, maple syrup, and mushrooms. This ability makes MAN1B1 an interesting potential drug target, as mannose has been shown to have a number of potential health benefits, including reducing inflammation and improving insulin sensitivity.

In addition to its role in carbohydrate metabolism, MAN1B1 is also involved in the regulation of inflammation and immune responses. This is important because MAN1B1 has been shown to play a role in the development and progression of a number of inflammatory diseases, including type 2 diabetes, rheumatoid arthritis, and inflammatory bowel disease.

One of the potential benefits of targeting MAN1B1 as a drug target is that it is relatively easy to manipulate the activity of this enzyme. This is because MAN1B1 is a protein that is expressed in high levels in many different tissues, which makes it relatively simple to target using small molecules or other types of therapeutics.

Another potential benefit of targeting MAN1B1 is that it is thought to be involved in a number of different biological processes that are important for overall health and wellbeing. This makes it an attractive target for drugs that are designed to promote health and prevent disease.

In conclusion, MAN1B1 is a protein that is expressed in various tissues throughout the body and is involved in the breakdown of mannose, a type of carbohydrate. It is also involved in the regulation of inflammation and immune responses, and is thought to play a role in a number of different biological processes that are important for overall health and wellbeing. As a result, MAN1B1 is an attractive potential drug target for the development of new treatments for a number of inflammatory diseases.

Protein Name: Mannosidase Alpha Class 1B Member 1

Functions: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)

The "MAN1B1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAN1B1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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