Understanding MAN1A2: A Potential Drug Target and Biomarker (G10905)

Target Name: MAN1A2

NCBI ID: G10905

MAN1A2

Understanding MAN1A2: A Potential Drug Target and Biomarker

MAN1A2 (MA1A2_HUMAN) is a protein that is expressed in various tissues of the human body. It is a member of the MA1A2 family, which is characterized by the presence of a single transmembrane domain and a carboxylic acid-rich cytoplasmic tail. MAN1A2 is known to play a role in various cellular processes, including cell signaling, cell adhesion, and tissue repair.

One of the main functions of MAN1A2 is its role in cell signaling. It is a positive regulator of the protein kinase A1 (APK) and is involved in the regulation of multiple signaling pathways, including the TGF-β pathway, the FGF pathway, and the Wnt pathway. MAN1A2 has been shown to play a key role in the regulation of cell proliferation, differentiation, and survival.

Another function of MAN1A2 is its role in cell adhesion. It is a critical regulator of tight junctions, which are a type of cell-cell adhesion that is necessary for the proper functioning of tissues and organs. MAN1A2 is known to play a key role in the regulation of tight junction formation and maintenance, as well as its disruption in various diseases, such as cancer.

In addition to its role in cell signaling and cell adhesion, MAN1A2 is also involved in the regulation of tissue repair. It is a critical regulator of the cell division cycle, and is shown to play a key role in the regulation of apoptosis, which is a normal form of cell death that is necessary for the development and maintenance of tissues and organs.

Due to its involvement in various cellular processes, MAN1A2 has been identified as a potential drug target and biomarker. Studies have shown that inhibiting MAN1A2 has been shown to have therapeutic effects in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Additionally, there are several drugs that are currently in development that target MAN1A2, including small molecules, peptides, and antibodies.

In conclusion, MAN1A2 is a protein that plays a critical role in various cellular processes in the human body. Its functions include cell signaling, cell adhesion, and tissue repair. As a result, it has been identified as a potential drug target and biomarker, and several drugs are currently in development that target MAN1A2. Further research is needed to fully understand the role of MAN1A2 in various diseases and to develop effective treatments.

Protein Name: Mannosidase Alpha Class 1A Member 2

Functions: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

The "MAN1A2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAN1A2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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