MANF Deficiency: Potential Drug Targets and Biomarkers (G7873)

Target Name: MANF

NCBI ID: G7873

MANF

MANF Deficiency: Potential Drug Targets and Biomarkers

MANF, or Mesencephalic Astrocyte-Derived Neurotrophic Factor, is a protein that is expressed in the glial cells of the central nervous system. Glial cells are a type of nerve cell that support and protect nerve fibers. Manifestations of MANF deficiency have been observed in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. As a result, MANF has been identified as a potential drug target and biomarker for these disorders.

The neurotrophic factor (NTF) family is a group of proteins that are characterized by the presence of a transmembrane domain and a cytoplasmic tail that is involved in various signaling pathways. MANF is a member of the NTF family and is expressed in the glial cells of the central nervous system. These cells are responsible for maintaining the structural and functional integrity of the nervous system and are a key part of the immune response to neurodegenerative diseases.

MANF is involved in the regulation of a variety of cellular processes that are critical for the survival and function of glial cells. One of the main functions of MANF is to stimulate the growth and survival of glial cells. It does this by inhibiting the activity of the protein kinase B, which is involved in cell growth and division. This means that MANF can promote the survival and proliferation of glial cells, which can help to maintain the number and function of these cells in the central nervous system.

Another function of MANF is to modulate the activity of the immune system. Glial cells are a major source of immune cells in the central nervous system, and they play a key role in the immune response to infection and inflammation. MANF is involved in the regulation of the activity of T cells, which are a critical part of the immune system. It does this by interacting with the protein PD-L1, which is involved in the regulation of immune cell function.

In addition to its functions in cell survival and immune regulation, MANF is also involved in the regulation of pain perception. Glial cells are involved in the perception of pain and are thought to play a key role in the development of chronic pain. MANF is involved in the regulation of pain perception by interacting with a protein called TRPV1. This protein is involved in the detection of temperature, pressure, and pain and is thought to be involved in the regulation of pain perception.

Manifestations of MANF deficiency have been observed in a variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Studies have shown that individuals with these disorders have lower levels of MANF in their brains compared to healthy individuals. Additionally, individuals with these disorders have lower levels of TrPV1 in their brains, which is consistent with the idea that MANF may play a role in modulating pain perception.

In conclusion, MANF is a protein that is expressed in the glial cells of the central nervous system and is involved in various cellular processes that are critical for the survival and function of these cells. Its role in cell survival and immune regulation makes it a potential drug target and biomarker for a variety of neurological disorders. Further research is needed to fully understand the functions of MANF in the central nervous system and to develop effective treatments for these disorders.

Protein Name: Mesencephalic Astrocyte Derived Neurotrophic Factor

Functions: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PubMed:29497057)

The "MANF Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MANF comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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